STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F59C12.3Uncharacterized protein. (519 aa)    
Predicted Functional Partners:
T25D1.2
Uncharacterized protein.
    
 
 0.922
pat-9
Paralysed Arrest at Two-fold.
   
 
 0.772
mab-21
Protein male abnormal 21; Acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate. Belongs to the mab-21 family.
      
 0.669
yap-1
Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging.
   
 
 0.643
nfm-1
FERM domain-containing protein.
   
 
 0.592
hecw-1
E3 ubiquitin-protein ligase hecw-1; E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours. Likely to act by inhibiting the neuropeptide receptor npr-1.
    
 
 0.542
Y92H12A.2
E3 ubiquitin-protein ligase.
   
 
 0.542
apb-3
AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family.
   
  
 0.538
wts-1
Serine/threonine-protein kinase WARTS homolog; Phosphorylates yap-1 which may negatively regulate yap-1 nuclear localization. Plays an essential role in larval development. Regulates growth, the formation of gut granules, lifespan and cell and body sizes probably in synergy with the TGF-beta sma/mab pathway. Does not appear to regulate apoptosis and proliferation. In addition, may synergize with the TGF-beta daf-7 dauer pathway to regulate entry into the dauer stage. Maintains the cellular integrity of intestinal cells by regulating the localization of apical actin and junctional proteins.
   
 
 0.467
frg-1
Protein FRG1 homolog; Binds to mRNA in a sequence-independent manner. May play a role in regulation of pre-mRNA splicing or in the assembly of rRNA into ribosomal subunits. May be involved in mRNA transport. May be involved in epigenetic regulation of muscle differentiation through regulation of activity of the histone-lysine N-methyltransferase KMT5B (By similarity); Belongs to the FRG1 family.
      
 0.465
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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