STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nhr-3Nuclear hormone receptor family member nhr-3; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family. (463 aa)    
Predicted Functional Partners:
cyp-33C1
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.672
C16C10.8
Uncharacterized protein C16C10.8.
    
 
 0.666
twk-8
TWiK family of potassium channels; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.
   
  
 0.635
gst-39
Glutathione S-Transferase.
      
 0.607
gei-8
Nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Plays a role in development and neuronal function. May play a role in muscle-specific oxidative mitochondrial metabolism.
    
 0.577
nhr-258
Nuclear Hormone Receptor family.
  
 
 
0.577
cyp-33C4
CYtochrome P450 family; Belongs to the cytochrome P450 family.
    
 
 0.566
svh-5
Uncharacterized protein.
  
 
 0.493
nhr-25
Nuclear hormone receptor family member nhr-25; Orphan nuclear receptor required during development. Plays a role in male tail tip morphogenesis regulating the expression of the transcription factor dmd-3 in a negative feedback loop.
   
 
0.490
wrk-1
Wrapper/Rega-1/Klingon homolog.
  
    0.483
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.