STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mls-1T-box transcription factor mls-1; Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37. (252 aa)    
Predicted Functional Partners:
mls-2
Homeobox domain-containing protein.
    
 
 0.855
unc-37
Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation.
    
 
 0.763
nhr-63
Nuclear Hormone Receptor family.
      
 0.690
hlh-8
Twist-related protein; Acts as a transcriptional regulator. Involved in postembryonic mesodermal cell fate specification. Activates ceh-24 and egl-15 during mesodermal patterning.
   
  
 0.667
grl-26
Ground-like domain-containing protein.
      
 0.667
nhr-46
Nuclear Hormone Receptor family.
      
 0.660
nhr-4
Nuclear hormone receptor family member nhr-4; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
      
 0.660
unc-62
Homeobox protein unc-62; Acts redundantly with ceh-20 and ceh-40 to perform overlapping roles during embryogenesis. Required for postembryonic development of the ectoderm, including the Q, V and P cell lineages, playing a crucial role in ensuring that these cells and their descendants undergo their invariant patterns of cell division, migration, fusion and morphogenesis. Has a role in the mig-13 pathway to promote anterior migration of neuroblasts in the Q lineage. Required for multiple roles in regulating vulva development. Belongs to the TALE/MEIS homeobox family.
      
 0.593
grh-1
Grainyhead transcription factor.
   
  
 0.581
mrpl-40
Mitochondrial Ribosomal Protein, Large.
      
 0.557
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.