node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C23H4.6 | H21P03.2 | C23H4.6a.1 | H21P03.2.1 | AAA_23 domain-containing protein. | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | 0.961 |
C23H4.6 | T27A3.7 | C23H4.6a.1 | T27A3.7.1 | AAA_23 domain-containing protein. | Phorbol-ester/DAG-type domain-containing protein. | 0.961 |
C23H4.6 | Y49E10.29 | C23H4.6a.1 | Y49E10.29.1 | AAA_23 domain-containing protein. | Uncharacterized protein. | 0.808 |
C23H4.6 | ZK1248.11 | C23H4.6a.1 | ZK1248.11.1 | AAA_23 domain-containing protein. | SP-RING-type domain-containing protein. | 0.961 |
C23H4.6 | mage-1 | C23H4.6a.1 | F40E3.2.1 | AAA_23 domain-containing protein. | Melanoma-Associated-antiGEn homolog. | 0.808 |
C23H4.6 | smc-3 | C23H4.6a.1 | Y47D3A.26b.1 | AAA_23 domain-containing protein. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.742 |
C23H4.6 | smc-4 | C23H4.6a.1 | F35G12.8.2 | AAA_23 domain-containing protein. | Structural maintenance of chromosomes protein 4; Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in [...] | 0.447 |
C23H4.6 | smc-5 | C23H4.6a.1 | C27A2.1.1 | AAA_23 domain-containing protein. | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.967 |
C23H4.6 | smc-6 | C23H4.6a.1 | F54D5.14.1 | AAA_23 domain-containing protein. | Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication. | 0.551 |
H21P03.2 | C23H4.6 | H21P03.2.1 | C23H4.6a.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | AAA_23 domain-containing protein. | 0.961 |
H21P03.2 | T27A3.7 | H21P03.2.1 | T27A3.7.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Phorbol-ester/DAG-type domain-containing protein. | 0.997 |
H21P03.2 | Y49E10.29 | H21P03.2.1 | Y49E10.29.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Uncharacterized protein. | 0.930 |
H21P03.2 | ZK1248.11 | H21P03.2.1 | ZK1248.11.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | SP-RING-type domain-containing protein. | 0.987 |
H21P03.2 | him-1 | H21P03.2.1 | F28B3.7a.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein 1; Involved in chromosome cohesion during cell cycle and in DNA repair (By similarity). Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate (By similarity). | 0.757 |
H21P03.2 | mage-1 | H21P03.2.1 | F40E3.2.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Melanoma-Associated-antiGEn homolog. | 0.972 |
H21P03.2 | smc-3 | H21P03.2.1 | Y47D3A.26b.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein 3; Involved in chromosome cohesion during cell cycle and in DNA repair. Involved in the repair of double strand breaks during mitosis and meiosis. Required for chromosome segregation during mitosis. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped (By similarity). At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chrom [...] | 0.822 |
H21P03.2 | smc-4 | H21P03.2.1 | F35G12.8.2 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein 4; Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin I complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Also a central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation. Both the condensin complex I and II play a role in [...] | 0.645 |
H21P03.2 | smc-5 | H21P03.2.1 | C27A2.1.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.997 |
H21P03.2 | smc-6 | H21P03.2.1 | F54D5.14.1 | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. | Structural maintenance of chromosomes protein 6 homolog smc-6; Core component of the smc-5/smc-6 complex. Involved in DNA double-strand break repair by promoting sister- chromatid homologous recombination during meiosis. Also plays a role in the DNA damage repair of ultraviolet (UV) radiation-induced DNA lesions. Promotes efficient DNA replication. | 0.969 |
T27A3.7 | C23H4.6 | T27A3.7.1 | C23H4.6a.1 | Phorbol-ester/DAG-type domain-containing protein. | AAA_23 domain-containing protein. | 0.961 |