node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acr-17 | acr-21 | F53E10.2b.1 | F27B3.2a.1 | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | AcetylCholine Receptor. | 0.561 |
acr-17 | exp-1 | F53E10.2b.1 | H35N03.1.1 | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | 0.738 |
acr-21 | acr-17 | F27B3.2a.1 | F53E10.2b.1 | AcetylCholine Receptor. | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.561 |
acr-21 | exp-1 | F27B3.2a.1 | H35N03.1.1 | AcetylCholine Receptor. | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | 0.752 |
acr-8 | exp-1 | ZC504.2.1 | H35N03.1.1 | Acetylcholine receptor 8. | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | 0.507 |
acr-8 | lev-8 | ZC504.2.1 | C35C5.5.1 | Acetylcholine receptor 8. | Uncharacterized protein. | 0.487 |
aex-2 | exp-1 | T14B1.2.1 | H35N03.1.1 | G-protein coupled receptor aex-2; G-protein coupled receptor for the nlp-40 neuropeptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation. Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine. | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | 0.545 |
cup-4 | exp-1 | C02C2.3.1 | H35N03.1.1 | Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | 0.561 |
cup-4 | pbo-5 | C02C2.3.1 | Y44A6E.1b.1 | Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.506 |
exp-1 | acr-17 | H35N03.1.1 | F53E10.2b.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | AcetylCholine Receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.738 |
exp-1 | acr-21 | H35N03.1.1 | F27B3.2a.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | AcetylCholine Receptor. | 0.752 |
exp-1 | acr-8 | H35N03.1.1 | ZC504.2.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Acetylcholine receptor 8. | 0.507 |
exp-1 | aex-2 | H35N03.1.1 | T14B1.2.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | G-protein coupled receptor aex-2; G-protein coupled receptor for the nlp-40 neuropeptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Plays a role in the defecation motor program, which is a coordinated series of three muscle contractions that occurs every 45 seconds. Specifically, acts in GABAergic neurons, such as AVL and DVB, to control the expulsion step of defecation. Required for fatty acid uptake and metabolism by intestinal cells and therefore regulates the levels of triglycerides in the intestine. | 0.545 |
exp-1 | cup-4 | H35N03.1.1 | C02C2.3.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Acetylcholine receptor-like protein cup-4; Thought to regulate endocytosis in coelomocytes through modulation of phospholipase C activity. Possible acetylcholine receptor; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.561 |
exp-1 | lev-8 | H35N03.1.1 | C35C5.5.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Uncharacterized protein. | 0.525 |
exp-1 | lgc-36 | H35N03.1.1 | F07B10.5.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.709 |
exp-1 | lgc-37 | H35N03.1.1 | ZC482.5.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Ligand-Gated ion Channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family. | 0.691 |
exp-1 | pbo-5 | H35N03.1.1 | Y44A6E.1b.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Proton-gated ion channel subunit pbo-5; Forms a proton-gated ion channel with pbo-6 that is activated by acidification of the posterior coelomic space, leading to posterior body wall muscle contraction (pBoc) during the defecation cycle. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. Does not bind neurotransmitters such as acetylcholine, gamma- aminobutyric acid, glycine, serotonin, glutamate or choline ; Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. | 0.701 |
exp-1 | unc-25 | H35N03.1.1 | Y37D8A.23a.1 | Gamma-aminobutyric acid receptor exp-1; GABA receptor that functions as an excitatory cation channel. Permeable to monovalent cations such as Na(+) and K(+). Has negligible divalent cation permeability. Does not act as a chloride channel. Mediates enteric muscle contractions required for defecation. Probably by regulating the defecation motor program, required for fatty acid uptake by intestinal cells. | Glutamic acid decarboxylase. | 0.546 |
lev-8 | acr-8 | C35C5.5.1 | ZC504.2.1 | Uncharacterized protein. | Acetylcholine receptor 8. | 0.487 |