STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snap-29Soluble NSF attachment protein 29; SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion; Belongs to the SNAP-25 family. (277 aa)    
Predicted Functional Partners:
vamp-8
V-SNARE coiled-coil homology domain-containing protein.
   
 0.999
syx-17
t-SNARE coiled-coil homology domain-containing protein.
   
 0.999
syx-6
Putative syntaxin 6; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.
    
 0.985
ykt-6
YKT6 (Yeast v-SNARE) homolog; Belongs to the synaptobrevin family.
    
 
 0.978
epg-8
Ectopic P Granules.
    
 0.976
snap-1
SNAP (Soluble NSF Attachment Protein) homolog.
   
 0.967
vamp-7
V-SNARE coiled-coil homology domain-containing protein.
     
 0.966
syx-5
Putative syntaxin-5; Potentially involved in docking of synaptic vesicles at presynaptic active zones; Belongs to the syntaxin family.
    
 0.950
syx-7
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
   
 0.941
unc-64
Syntaxin-1A homolog; Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation. Essential for embryonic viability and development. Has a role in dauer formation and adult life span. Required for locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin-23 and phospholipase plc-3 and upstream of innexin unc-7 and egl-4/PKG in ALA neurons, involved in the decrease in pharyngeal pumping during the qui [...]
   
 0.935
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.