node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C47G2.3 | K02F3.2 | C47G2.3.1 | K02F3.2b.1 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | 0.531 |
C47G2.3 | cox-11 | C47G2.3.1 | JC8.5a.1 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Cytochrome OXidase assembly protein. | 0.636 |
C47G2.3 | phb-2 | C47G2.3.1 | T24H7.1.2 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. | 0.493 |
C47G2.3 | psmd-9 | C47G2.3.1 | C44B7.1.1 | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. | 0.568 |
K02F3.2 | C47G2.3 | K02F3.2b.1 | C47G2.3.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | 0.531 |
K02F3.2 | bpnt-1 | K02F3.2b.1 | ZK430.2.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | 3'(2'), 5'-BisPhosphate NucleoTidase 1 homolog. | 0.548 |
K02F3.2 | chin-1 | K02F3.2b.1 | BE0003N10.2.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | CHImaeriN (Rac-GTPase-activating protein) homolog. | 0.697 |
K02F3.2 | cox-11 | K02F3.2b.1 | JC8.5a.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Cytochrome OXidase assembly protein. | 0.468 |
K02F3.2 | fmi-1 | K02F3.2b.1 | F15B9.7a.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | FlaMIngo (Cadherin plus 7TM domain) homolog. | 0.660 |
K02F3.2 | gck-3 | K02F3.2b.1 | Y59A8B.23a.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.534 |
K02F3.2 | glt-1 | K02F3.2b.1 | C12D12.2a.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Excitatory amino acid transporter; Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium (By similarity). | 0.670 |
K02F3.2 | glt-5 | K02F3.2b.1 | Y53C12A.2.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Amino acid transporter. | 0.922 |
K02F3.2 | phb-2 | K02F3.2b.1 | T24H7.1.2 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. | 0.487 |
K02F3.2 | psmd-9 | K02F3.2b.1 | C44B7.1.1 | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | Probable 26S proteasome non-ATPase regulatory subunit 9; Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC); Belongs to the proteasome subunit p27 family. | 0.470 |
bpnt-1 | K02F3.2 | ZK430.2.1 | K02F3.2b.1 | 3'(2'), 5'-BisPhosphate NucleoTidase 1 homolog. | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | 0.548 |
bpnt-1 | gck-3 | ZK430.2.1 | Y59A8B.23a.1 | 3'(2'), 5'-BisPhosphate NucleoTidase 1 homolog. | Germinal center kinase 3; Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation- mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes including the tubular formation of the excretory canals, the formation of the intestine and the progression through larval stages. In addition, required for germ line development by controlling meiosis and chromosomal segregation during spermatogenesis. [...] | 0.400 |
chin-1 | K02F3.2 | BE0003N10.2.1 | K02F3.2b.1 | CHImaeriN (Rac-GTPase-activating protein) homolog. | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | 0.697 |
cox-11 | C47G2.3 | JC8.5a.1 | C47G2.3.1 | Cytochrome OXidase assembly protein. | Mitochondrial import inner membrane translocase subunit tim-22; Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). | 0.636 |
cox-11 | K02F3.2 | JC8.5a.1 | K02F3.2b.1 | Cytochrome OXidase assembly protein. | Probable calcium-binding mitochondrial carrier K02F3.2; Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. | 0.468 |
cox-11 | phb-2 | JC8.5a.1 | T24H7.1.2 | Cytochrome OXidase assembly protein. | Mitochondrial prohibitin complex protein 2; PHB proteins are essential during embryonic development and are required for somatic and germline differentiation in the larval gonad. A deficiency in PHB proteins results in altered mitochondrial biogenesis in body wall muscle cells. | 0.675 |