node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
act-5 | arp-1 | T25C8.2.2 | Y53F4B.22a.1 | ACTin. | Actin-Related Proteins; Belongs to the actin family. | 0.608 |
act-5 | arx-2 | T25C8.2.2 | K07C5.1.1 | ACTin. | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). | 0.813 |
act-5 | atn-1 | T25C8.2.2 | W04D2.1a.1 | ACTin. | AcTiniN. | 0.998 |
act-5 | cyk-1 | T25C8.2.2 | F11H8.4b.1 | ACTin. | CYtoKinesis defect. | 0.900 |
act-5 | daam-1 | T25C8.2.2 | F56E10.2a.2 | ACTin. | FH2 domain-containing protein. | 0.888 |
act-5 | gsnl-1 | T25C8.2.2 | K06A4.3.1 | ACTin. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.997 |
act-5 | pfn-3 | T25C8.2.2 | K03E6.6.1 | ACTin. | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. | 0.999 |
act-5 | rho-1 | T25C8.2.2 | Y51H4A.3a.1 | ACTin. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.989 |
act-5 | twf-2 | T25C8.2.2 | F38E9.5.2 | ACTin. | TWinFilin actin binding protein homolog. | 0.920 |
act-5 | unc-60 | T25C8.2.2 | C38C3.5.1 | ACTin. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.999 |
arp-1 | act-5 | Y53F4B.22a.1 | T25C8.2.2 | Actin-Related Proteins; Belongs to the actin family. | ACTin. | 0.608 |
arp-1 | arx-2 | Y53F4B.22a.1 | K07C5.1.1 | Actin-Related Proteins; Belongs to the actin family. | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). | 0.698 |
arp-1 | atn-1 | Y53F4B.22a.1 | W04D2.1a.1 | Actin-Related Proteins; Belongs to the actin family. | AcTiniN. | 0.730 |
arp-1 | daam-1 | Y53F4B.22a.1 | F56E10.2a.2 | Actin-Related Proteins; Belongs to the actin family. | FH2 domain-containing protein. | 0.445 |
arp-1 | gsnl-1 | Y53F4B.22a.1 | K06A4.3.1 | Actin-Related Proteins; Belongs to the actin family. | Gelsolin-like protein 1; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). Binds actin but does not nucleate actin polymerization, albeit slows down elongation by blocking the barbed ends. By promoting actin depolymerization, required for the elimination of presynaptic components downstream of the egl-1, ced-4 and ced-3 apoptotic pathway during larval development. Belongs to the villin/gelsolin family. | 0.765 |
arp-1 | pfn-3 | Y53F4B.22a.1 | K03E6.6.1 | Actin-Related Proteins; Belongs to the actin family. | Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Also binds to poly(L-proline) and phosphatidylinositol 4,5-bisphosphate micelles. | 0.873 |
arp-1 | rho-1 | Y53F4B.22a.1 | Y51H4A.3a.1 | Actin-Related Proteins; Belongs to the actin family. | Ras-like GTP-binding protein rhoA; Required for ventral migration of epidermal cells during ventral enclosure in the embryo and for cell elongation. Also required for ventral migration of P cells during larval development. Involved in asymmetric spindle positioning during anaphase and establishment of cell polarity during embryo development. In adults, involved in regulation of multiple processes including locomotion, pharyngeal pumping, fecundity, ovulation, defecation and body morphology. In body wall muscles, regulates organization of myosin thick filaments downstream of unc-89. Ass [...] | 0.474 |
arp-1 | twf-2 | Y53F4B.22a.1 | F38E9.5.2 | Actin-Related Proteins; Belongs to the actin family. | TWinFilin actin binding protein homolog. | 0.610 |
arp-1 | unc-60 | Y53F4B.22a.1 | C38C3.5.1 | Actin-Related Proteins; Belongs to the actin family. | Actin-depolymerizing factor 2, isoform c; Depolymerizes growing actin filaments in muscle cells; required for the assembly of actin filaments into the functional contractile myofilament lattice of muscle. Belongs to the actin-binding proteins ADF family. | 0.867 |
arx-2 | act-5 | K07C5.1.1 | T25C8.2.2 | Actin-related protein 2; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). | ACTin. | 0.813 |