STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ifa-4Intermediate filament protein ifa-4; Cytoplasmic intermediate filaments provide mechanical strength to cells. Non-essential protein. (575 aa)    
Predicted Functional Partners:
ifb-1
Intermediate filament protein ifb-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Required in morphogenesis and epidermal integrity. Probable component of embryonic epidermal attachment structures. Functions in larval muscle attachment independently of ifa-2.
  
0.858
exc-9
LIM zinc-binding domain-containing protein.
   
 
 0.773
ifp-1
Intermediate filament protein ifp-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.
   
0.728
ifc-1
Intermediate filament protein ifc-1; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein.
  
0.717
ifc-2
Intermediate filament protein ifc-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein, although its absence leads to mild defects in locomotion.
   
0.705
hsp-12.1
SHSP domain-containing protein; Belongs to the small heat shock protein (HSP20) family.
   
 
 0.676
exc-1
IRG-type G domain-containing protein.
   
  
 0.665
ifa-1
Intermediate filament protein ifa-1; Cytoplasmic intermediate filaments make up the structural component of the cytoskeleton providing mechanical strength to cells. Essential protein required during embryogenesis especially for survival past the L1 larva stage, involved in intestine morphogenesis.
  
0.657
mua-6
Intermediate filament protein ifa-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Essential protein, involved in attachment structures in epidermal cells that connect muscles to the external cuticle. Probably acts by forming hypodermal hemidesmosome complexes that help mediate muscle-cuticle force transduction. Although expressed during embryogenesis, it is not required for embryonic development of muscle- cuticle linkages nor for the localization of other proteins to the hemidesmosomes in embryos.
  
0.642
erm-1
FERM domain-containing protein.
   
  
 0.627
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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