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hmp-2 protein (Caenorhabditis elegans) - STRING interaction network
"hmp-2" - Beta-catenin-like protein hmp-2 in Caenorhabditis elegans
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hmp-2Beta-catenin-like protein hmp-2; Required for cell migration during body enclosure and cell shape changes during body elongation. Plays a role in recruitment of the cadherin protein hmr-1 to adherens junctions (704 aa)    
Predicted Functional Partners:
hmp-1
Alpha-catenin-like protein hmp-1; Required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as pac-1; Belongs to the vinculin/alpha-catenin family (930 aa)
     
  0.999
hmr-1
Cadherin-related hmr-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for adherens junction assembly and connecting adherens junctions to the cytoskeleton (2920 aa)
     
  0.999
pop-1
Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase (438 aa)
       
  0.998
apr-1
Adenomatous polyposis coli protein-related protein 1; Has a role in endoderm cell specification and pharyngeal development. Required for the migration of epithelial cells, organization of the anterior seam cells and ceh- 13 expression during embryo morphogenesis. Prevents hyperactivation of the Wnt signaling pathway during endoderm development, probably by preventing hmp-2 nuclear translocation. During larval development, apr-1 is required for expression of lin-39 in P3-8.p. Shown to negatively regulate Wnt signaling in vulval precursor cells. Has a role in cell division by establishin [...] (1188 aa)
     
 
  0.992
jac-1
Juxtamembrane domain-associated catenin; May act as a positive modulator of hmr-1 function during epidermal morphogenesis. Required for proper localization of other junctional components, such as pac-1; Belongs to the beta-catenin family (1254 aa)
     
  0.992
lin-23
F-box/WD repeat-containing protein lin-23; Functions cell autonomously to negatively regulate cell cycle progression. Required to restrain cell proliferation in response to developmental cues. Probably recognizes and binds to some proteins and promotes their ubiquitination and degradation (By similarity) (665 aa)
     
  0.987
deb-1
Vinculin; Involved in cell adhesion (By similarity). May be involved in the attachment of the actin-based microfilaments to the plasma membrane. Involved in ovulation; Belongs to the vinculin/alpha-catenin family (1010 aa)
     
  0.983
gsk-3
Glycogen synthase kinase-3; Phosphorylates oma-1, a regulator of the oocyte-to- embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibitin [...] (362 aa)
     
  0.977
C44H4.6
Protein C44H4.6 (C44H4.6) mRNA, complete cds; Belongs to the protein kinase superfamily (367 aa)
     
  0.974
src-2
Tyrosine protein-kinase src-2; Non-receptor tyrosine-protein kinase which may play a role in larval and pharynx development. Unlike src-1, does not play a role in embryonic development (507 aa)
       
  0.974
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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