STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rba-1Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. (412 aa)    
Predicted Functional Partners:
chaf-2
WD_REPEATS_REGION domain-containing protein.
   
 
 0.988
mes-6
Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...]
   
 0.970
mes-2
Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...]
   
 0.969
lin-40
Uncharacterized protein.
   
 0.967
chaf-1
CHromatin Assembly Factor.
   
 
 0.957
mrg-1
MRG domain-containing protein.
   
 
 0.952
lin-9
Protein lin-9; Synthetic multivulva class B (synMuvB) protein. SynMuvB proteins are required to repress the induction of vulval development by Ras signaling and probably act by forming the multiprotein DRM complex that represses transcription. Required for the development of sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis.
   
 0.939
hat-1
Hat1_N domain-containing protein.
   
 
 0.934
chd-3
Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification.
   
 0.930
hda-3
Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily.
   
 0.917
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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