node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
chaf-1 | chaf-2 | T06D10.2.1 | Y71G12B.1a.1 | CHromatin Assembly Factor. | WD_REPEATS_REGION domain-containing protein. | 0.998 |
chaf-1 | rba-1 | T06D10.2.1 | K07A1.11.1 | CHromatin Assembly Factor. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.957 |
chaf-2 | chaf-1 | Y71G12B.1a.1 | T06D10.2.1 | WD_REPEATS_REGION domain-containing protein. | CHromatin Assembly Factor. | 0.998 |
chaf-2 | rba-1 | Y71G12B.1a.1 | K07A1.11.1 | WD_REPEATS_REGION domain-containing protein. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.988 |
chd-3 | hda-3 | T14G8.1.1 | R06C1.1.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.852 |
chd-3 | lin-40 | T14G8.1.1 | T27C4.4a.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Uncharacterized protein. | 0.980 |
chd-3 | mes-2 | T14G8.1.1 | R06A4.7.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] | 0.555 |
chd-3 | rba-1 | T14G8.1.1 | K07A1.11.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.930 |
hat-1 | hda-3 | M03C11.4.1 | R06C1.1.1 | Hat1_N domain-containing protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.515 |
hat-1 | mes-2 | M03C11.4.1 | R06A4.7.1 | Hat1_N domain-containing protein. | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] | 0.462 |
hat-1 | rba-1 | M03C11.4.1 | K07A1.11.1 | Hat1_N domain-containing protein. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.934 |
hda-3 | chd-3 | R06C1.1.1 | T14G8.1.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | 0.852 |
hda-3 | hat-1 | R06C1.1.1 | M03C11.4.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Hat1_N domain-containing protein. | 0.515 |
hda-3 | lin-40 | R06C1.1.1 | T27C4.4a.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Uncharacterized protein. | 0.880 |
hda-3 | mes-2 | R06C1.1.1 | R06A4.7.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Histone-lysine N-methyltransferase mes-2; Polycomb group (PcG) protein. Catalytic subunit of a the mes- 2/mes-3/mes-6 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes-6 complex may participate in the global inactivation of the X c [...] | 0.681 |
hda-3 | mes-6 | R06C1.1.1 | C09G4.5.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Polycomb protein mes-6; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. The mes-2/mes-3/mes- 6 complex may participate in the global inactivation of the X chromosomes in germline cells. The complex may act via methylation of histone H3 'Lys-27', rendering chromatin heritably changed in its expressibility. This complex is required to ex [...] | 0.593 |
hda-3 | mrg-1 | R06C1.1.1 | Y37D8A.9b.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | MRG domain-containing protein. | 0.849 |
hda-3 | rba-1 | R06C1.1.1 | K07A1.11.1 | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | Probable histone-binding protein rba-1; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Plays a role in regulating cell cycle progression. Required to repress the induction of vulval development by Ras signaling. In association with the zinc finger protein ztf-11, negatively regulates the expression of non- neuronal genes during neurogenesis. Belongs to the WD repeat RBAP46/RBAP48/MSI1 family. | 0.917 |
lin-40 | chd-3 | T27C4.4a.1 | T14G8.1.1 | Uncharacterized protein. | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | 0.980 |
lin-40 | hda-3 | T27C4.4a.1 | R06C1.1.1 | Uncharacterized protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.880 |