node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0334.5 | coq-1 | B0334.5.1 | C24A11.9.1 | Uncharacterized protein. | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | 0.946 |
B0334.5 | coq-2 | B0334.5.1 | F57B9.4a.1 | Uncharacterized protein. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family. | 0.878 |
B0334.5 | coq-3 | B0334.5.1 | Y57G11C.11a.2 | Uncharacterized protein. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.603 |
B0334.5 | coq-6 | B0334.5.1 | K07B1.2.1 | Uncharacterized protein. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family. | 0.802 |
B0334.5 | daf-36 | B0334.5.1 | C12D8.5.1 | Uncharacterized protein. | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.491 |
Y73F8A.27 | coq-1 | Y73F8A.27.1 | C24A11.9.1 | 2Fe-2S ferredoxin-type domain-containing protein. | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | 0.588 |
Y73F8A.27 | coq-2 | Y73F8A.27.1 | F57B9.4a.1 | 2Fe-2S ferredoxin-type domain-containing protein. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family. | 0.485 |
Y73F8A.27 | coq-3 | Y73F8A.27.1 | Y57G11C.11a.2 | 2Fe-2S ferredoxin-type domain-containing protein. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.729 |
Y73F8A.27 | coq-4 | Y73F8A.27.1 | T03F1.2.1 | 2Fe-2S ferredoxin-type domain-containing protein. | Ubiquinone biosynthesis protein coq-4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.415 |
Y73F8A.27 | coq-5 | Y73F8A.27.1 | ZK652.9.1 | 2Fe-2S ferredoxin-type domain-containing protein. | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). | 0.417 |
Y73F8A.27 | coq-6 | Y73F8A.27.1 | K07B1.2.1 | 2Fe-2S ferredoxin-type domain-containing protein. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family. | 0.847 |
Y73F8A.27 | coq-8 | Y73F8A.27.1 | C35D10.4.1 | 2Fe-2S ferredoxin-type domain-containing protein. | Atypical kinase coq-8, mitochondrial; Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: either acts as protein kinase that phosphorylates other proteins in the CoQ complex to stabilize their interactions or acts as a small molecule kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. | 0.434 |
Y73F8A.27 | daf-36 | Y73F8A.27.1 | C12D8.5.1 | 2Fe-2S ferredoxin-type domain-containing protein. | Cholesterol 7-desaturase; Catalyzes the production of 7-dehydrocholesterol (7-DHC) by the desaturation of the C7-C8 single bond of cholesterol. This reaction is the first step in the synthesis of the steroid hormone Delta(7)- dafachronic acid. Dafachronic acids bind directly to the nuclear hormone receptor (NHR) daf-12, suppressing dauer formation and inducing reproductive growth. | 0.961 |
coq-1 | B0334.5 | C24A11.9.1 | B0334.5.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | Uncharacterized protein. | 0.946 |
coq-1 | Y73F8A.27 | C24A11.9.1 | Y73F8A.27.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | 2Fe-2S ferredoxin-type domain-containing protein. | 0.588 |
coq-1 | coq-2 | C24A11.9.1 | F57B9.4a.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate; Belongs to the UbiA prenyltransferase family. | 0.995 |
coq-1 | coq-3 | C24A11.9.1 | Y57G11C.11a.2 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.974 |
coq-1 | coq-4 | C24A11.9.1 | T03F1.2.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | Ubiquinone biosynthesis protein coq-4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.969 |
coq-1 | coq-5 | C24A11.9.1 | ZK652.9.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). | 0.987 |
coq-1 | coq-6 | C24A11.9.1 | K07B1.2.1 | COenzyme Q (Ubiquinone) biosynthesis; Belongs to the FPP/GGPP synthase family. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6; Belongs to the UbiH/COQ6 family. | 0.971 |