node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Y50D7A.13 | cri-2 | Y50D7A.13a.1 | K07C11.5.2 | ZnMc domain-containing protein. | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | 0.729 |
Y50D7A.13 | timp-1 | Y50D7A.13a.1 | K07C11.3.1 | ZnMc domain-containing protein. | NTR domain-containing protein. | 0.729 |
Y50D7A.13 | zmp-1 | Y50D7A.13a.1 | EGAP1.3.1 | ZnMc domain-containing protein. | Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. | 0.499 |
Y50D7A.13 | zmp-2 | Y50D7A.13a.1 | H19M22.3a.1 | ZnMc domain-containing protein. | Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol. | 0.489 |
Y50D7A.13 | zmp-3 | Y50D7A.13a.1 | C31B8.8.1 | ZnMc domain-containing protein. | Matrix metalloproteinase-C; Metalloproteinase. | 0.461 |
Y50D7A.13 | zmp-5 | Y50D7A.13a.1 | H36L18.1.1 | ZnMc domain-containing protein. | ZnMc domain-containing protein. | 0.466 |
adm-4 | cri-2 | ZK154.7.1 | K07C11.5.2 | Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development. | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | 0.659 |
adm-4 | timp-1 | ZK154.7.1 | K07C11.3.1 | Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development. | NTR domain-containing protein. | 0.659 |
adm-4 | zmp-6 | ZK154.7.1 | T21D11.1.1 | Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development. | ZnMc domain-containing protein. | 0.506 |
cri-2 | Y50D7A.13 | K07C11.5.2 | Y50D7A.13a.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | ZnMc domain-containing protein. | 0.729 |
cri-2 | adm-4 | K07C11.5.2 | ZK154.7.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | Disintegrin and metalloproteinase domain-containing protein 17 homolog; Metalloprotease (By similarity). Acts together with protease sup-17 to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision. By modulating lin-12/Notch signaling, plays a role in germline development. | 0.659 |
cri-2 | gon-1 | K07C11.5.2 | F25H8.3b.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] | 0.769 |
cri-2 | mig-17 | K07C11.5.2 | F57B7.4.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | Metalloprotease mig-17; Metalloprotease. Acts in the basement membrane to control directional migration of distal tip cells (DTCs) along the body wall basement membranes, a key step that promotes gonad morphogenesis. Regulates DTC migration probably by recruiting fibulin fbl-1, type IV collagen let-2 and nidogen nid-1 to the gonad basement membrane thereby promoting the remodeling of the basement membrane. During larval development and probably upstream of basement membrane proteins fbl-1, let-2 and nid-1, regulates pharynx length, probably by regulating pharyngeal cell length. Does no [...] | 0.814 |
cri-2 | timp-1 | K07C11.5.2 | K07C11.3.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | NTR domain-containing protein. | 0.560 |
cri-2 | zmp-1 | K07C11.5.2 | EGAP1.3.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | Matrix metalloproteinase-A; Metalloprotease which, together with cadherin cdh-3 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development probably by promoting the degradation of the basement membrane separating the gonad from the vulva epithelium. | 0.637 |
cri-2 | zmp-2 | K07C11.5.2 | H19M22.3a.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | Matrix metalloproteinase-B; Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed. Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol. | 0.729 |
cri-2 | zmp-3 | K07C11.5.2 | C31B8.8.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | Matrix metalloproteinase-C; Metalloproteinase. | 0.738 |
cri-2 | zmp-5 | K07C11.5.2 | H36L18.1.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | ZnMc domain-containing protein. | 0.729 |
cri-2 | zmp-6 | K07C11.5.2 | T21D11.1.1 | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | ZnMc domain-containing protein. | 0.769 |
gon-1 | cri-2 | F25H8.3b.1 | K07C11.5.2 | A disintegrin and metalloproteinase with thrombospondin motifs gon-1; Secreted metalloprotease required for distal tip cell (DTC) migration along the body wall basement membranes, a key step that promotes gonad morphogenesis. Probably acts by remodeling the basement membrane during cell migration. Required to restrict presynaptic growth at the neuromuscular junctions (NMJ) in late larval stage and in adult motor neurons, probably by controlling collagen IV emb-9 degradation, a component of the synapse basement membrane. Also involved in the organization of adult muscle morphology. Has [...] | Putative metalloproteinase inhibitor tag-225; Complexes with metalloproteinases and irreversibly inactivates them by binding to their catalytic zinc cofactor. Belongs to the protease inhibitor I35 (TIMP) family. | 0.769 |