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mek-1 protein (Caenorhabditis elegans) - STRING interaction network
"mek-1" - Dual specificity mitogen-activated protein kinase kinase mek-1 in Caenorhabditis elegans
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second shell of interactors
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proteins of unknown 3D structure
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some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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mek-1Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] (347 aa)    
Predicted Functional Partners:
kgb-1
GLH-binding kinase 1; Mitogen-activated protein kinase which is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. Phosphorylates the transcription factor fos-1 which prevents fos-1 dimerization and promoter binding and results in activation of target genes including F53A9.2/kreg-1 and lys-3/kreg-2. Phosphorylates jun-1 and activates the AP-1 transcription factor which is a heterodimer of jun-1 and fos-1. Phosphorylates glh-1 in vitro which may play a role in controlling glh-1 protein levels in the germline by targeting it for degradation by the proteasome. R [...] (390 aa)
   
  0.988
jnk-1
Stress-activated protein kinase jnk-1; Serine/threonine-protein kinase which responds to activation by environmental stress by phosphorylating a number of transcription factors such as daf-16, and thus regulates transcriptional activity. By phosphorylating daf-16, plays a role in daf-16 nuclear translocation in intestinal cells in response to environmental stresses such as heat and oxidative stresses. Downstream of jkk-1, may coordinate locomotion via type-D GABAergic motoneurons and regulates synaptic vesicle transport in conjunction with unc-16. Independently of jkk-1, may regulate s [...] (463 aa)
   
0.965
trf-1
TNF Receptor Associated Factor (TRAF) homolog; Protein TRF-1 (trf-1) mRNA, complete cds (462 aa)
       
  0.947
mkk-4
MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily (363 aa)
   
 
0.942
VZC374L.1
SAPK/ERK kinase; Protein VZC374L.1 (VZC374L.1) mRNA, complete cds (359 aa)
   
 
0.939
ZC449.3
SAPK/ERK kinase; Protein ZC449.3, isoform b; Belongs to the protein kinase superfamily (411 aa)
   
0.933
pik-1
Pelle/IL-1 receptor associated Kinase (IRAK); Protein PIK-1, isoform b (pik-1) mRNA, complete cds; Belongs to the protein kinase superfamily (485 aa)
   
0.928
Y110A7A.2
Protein Y110A7A.2 (Y110A7A.2) mRNA, complete cds (335 aa)
       
  0.921
jkk-1
Dual specificity mitogen-activated protein kinase kinase jkk-1; Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D- type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-1. Positively regulates lifespan. Upon environmental stress such as heat stress regulates daf-16 nuclear translocation probably by activating jnk-1. Regulates germline cell apoptosis in response to heavy met [...] (435 aa)
   
   
0.913
F35C8.1
SAPK/ERK kinase; Protein F35C8.1 (F35C8.1) mRNA, complete cds (360 aa)
   
   
0.910
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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