STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cpi-1Cystatin cpi-1; Cysteine protease inhibitor which inhibits members of the peptidase C1 family. Does not inhibit asparaginyl endopeptidase. May play a protective role against exogenous cysteine proteases derived from soil bacteria or fungi, or rotting fruits and vegetation. Belongs to the cystatin family. (139 aa)    
Predicted Functional Partners:
scl-3
SCP domain-containing protein; Belongs to the CRISP family.
   
  
 0.749
ttr-51
TransThyretin-Related family domain.
   
  
 0.737
C53B7.2
TIL domain-containing protein.
   
  
 0.723
C23H5.8
Uncharacterized protein.
   
  
 0.707
cccp-1
CARD domain-containing protein.
      
 0.698
agmo-1
Alkylglycerol monooxygenase; Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids; Belongs to the sterol desaturase family. TMEM195 subfamily.
   
  
 0.674
pab-2
Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.
   
 
 0.669
nkb-3
Probable sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane (By similarity). Implicated in genomic response to various soil bacteria that affects fitness, lifespan and brood size.
   
  
 0.598
Y43F8B.1
Uncharacterized protein.
   
  
 0.552
E04F6.4
Uncharacterized protein.
   
  
 0.549
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.