STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgp-1Multidrug resistance protein pgp-1; Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells; Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1321 aa)    
Predicted Functional Partners:
tmd-2
TropoMoDulin.
    
 
 0.669
pgp-10
p-GlycoProtein related.
  
 
0.641
pgp-11
p-GlycoProtein related.
  
 
0.641
pgp-3
Multidrug resistance protein pgp-3; Mediates ATP-dependent export of organic anions and xenobiotics from the cytoplasm. Hydrolyzes ATP with low efficiency (By similarity); Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
  
 
0.631
unc-94
Tropomodulin; Acts as the pointed end capping protein which maintains the length and dynamics of the actin filament. Blocks the elongation and depolymerization of the actin filaments at the pointed end (By similarity); Belongs to the tropomodulin family.
    
 
 0.620
ifb-2
Intermediate filament protein ifb-2; Cytoplasmic intermediate filaments provide mechanical strength to cells. Not essential protein. Component of the terminal web (organelle-depleted, intermediate filament-rich layer of cytoplasm that underlies the apical microvilli of polarized epithelial cells) in embryonic through to adult gut cells. Correct localization of filaments requires let-413.
   
 
 0.619
haf-6
HAlF transporter (PGP related).
  
 
0.602
abt-1
ABC transporter domain-containing protein.
  
 
 0.599
avr-15
Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.597
pgp-12
p-GlycoProtein related.
  
 
0.589
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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