STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
asp-14Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family. (366 aa)    
Predicted Functional Partners:
aph-2
Nicastrin; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
    
 
 0.894
pen-2
Gamma-secretase subunit pen-2; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch (glp-1 or lin-12). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Belongs to the PEN-2 family.
      
 0.825
cpr-1
Gut-specific cysteine proteinase; Thiol protease. Has a role as a digestive enzyme. Belongs to the peptidase C1 family.
   
 0.780
cpr-5
Cathepsin B-like cysteine proteinase 5; Belongs to the peptidase C1 family.
   
 
 0.730
asp-3
Aspartic protease 3; Aspartic protease (Probable). Part of the necrosis cell death pathway. Involved in neuronal cell degeneration. Involved in heat stress response.
  
0.723
aph-1
Gamma-secretase subunit aph-1; Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2.
      
 0.699
Y16B4A.2
Carboxypeptidase; Belongs to the peptidase S10 family.
   
 
 0.674
K10C2.1
Carboxypeptidase; Belongs to the peptidase S10 family.
   
 
 0.617
asp-6
Aspartic protease 6; Aspartic protease; Belongs to the peptidase A1 family.
  
 
0.606
asp-8
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
  
 
 
0.604
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.