Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gcna-1 | mix-1 | ZK328.4.1 | M106.1.1 | SprT-like domain-containing protein. | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | 0.429 |
| gcna-1 | smo-1 | ZK328.4.1 | K12C11.2.1 | SprT-like domain-containing protein. | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.746 |
| gcna-1 | spo-11 | ZK328.4.1 | T05E11.4a.1 | SprT-like domain-containing protein. | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.698 |
| gcna-1 | tdpt-1 | ZK328.4.1 | Y63D3A.4.1 | SprT-like domain-containing protein. | 5'-tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase 2 (top2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals; Belongs to the CCR4/nocturin family. TTRAP/TDP2 subfamily. | 0.569 |
| gcna-1 | top-1 | ZK328.4.1 | M01E5.5a.2 | SprT-like domain-containing protein. | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remo [...] | 0.725 |
| gcna-1 | top-2 | ZK328.4.1 | K12D12.1.1 | SprT-like domain-containing protein. | DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] | 0.851 |
| gcna-1 | top-3 | ZK328.4.1 | Y56A3A.27.1 | SprT-like domain-containing protein. | DNA topoisomerase 3; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Fina [...] | 0.549 |
| mcm-7 | mix-1 | F32D1.10.1 | M106.1.1 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | 0.673 |
| mcm-7 | smc-5 | F32D1.10.1 | C27A2.1.1 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.654 |
| mcm-7 | smo-1 | F32D1.10.1 | K12C11.2.1 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | Small ubiquitin-related modifier; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex aos-1-uba-2 and linkage to the E2 enzyme ubc-9, and can be promoted by an E3 ligase such as gei-17. Required for embryonic dev [...] | 0.476 |
| mcm-7 | top-1 | F32D1.10.1 | M01E5.5a.2 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remo [...] | 0.576 |
| mcm-7 | top-2 | F32D1.10.1 | K12D12.1.1 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] | 0.825 |
| mix-1 | gcna-1 | M106.1.1 | ZK328.4.1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | SprT-like domain-containing protein. | 0.429 |
| mix-1 | mcm-7 | M106.1.1 | F32D1.10.1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.673 |
| mix-1 | smc-5 | M106.1.1 | C27A2.1.1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | 0.769 |
| mix-1 | spo-11 | M106.1.1 | T05E11.4a.1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | Meiotic recombination protein spo-11; Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. | 0.463 |
| mix-1 | top-1 | M106.1.1 | M01E5.5a.2 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | DNA topoisomerase 1; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)- enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus remo [...] | 0.413 |
| mix-1 | top-2 | M106.1.1 | K12D12.1.1 | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | DNA topoisomerase 2 top-2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks (By similarity). Essential during mitosis in the adult germline and during embryogenesis for proper segregation of daughter chromosomes. Required for centromere resolution during mitosis. Required for chromosome segregation in anaphase of meiosis I during spermatogenesis. Promotes cleavage furrow stability during cytokinesis upon the presence of chromatin obstructions. Promotes DNA break formation upon zygotic genome [...] | 0.839 |
| smc-5 | mcm-7 | C27A2.1.1 | F32D1.10.1 | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.654 |
| smc-5 | mix-1 | C27A2.1.1 | M106.1.1 | Structural maintenance of chromosomes protein 5; Core component of the smc-5/smc-6 complex. Functions in DNA double strand break repair by promoting sister- chromatid homologous recombination during meiosis. Acts in a DNA repair pathway for removal of ionizing radiation- and ultraviolet (UV) radiation-induced DNA lesions that is distinct from classical nucleotide excision repair and the translesion synthesis pathway. Also involved in the recovery of stalled replication forks. Belongs to the SMC family. SMC5 subfamily. | Mitotic chromosome and X-chromosome-associated protein mix-1; Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners. Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases. Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity). Central component o [...] | 0.769 |
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