STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pros-1Homeobox protein prospero homolog 1; Transcription factor involved in developmental processes (By similarity). Controls the transcription of genes required for excretory canal formation. (594 aa)    
Predicted Functional Partners:
ran-5
RanBD1 domain-containing protein.
      
 0.795
nhr-56
NR LBD domain-containing protein.
   
 
 0.688
ceh-53
Homeobox domain-containing protein.
   
 
 0.653
ceh-34
Homeobox protein ceh-34; Acts as a transcription regulator. Binds to the cis-regulatory element of proapoptotic factor egl-1 gene and together with eya-1 activates egl-1 expression to promote motor neuron M4 sister cell apoptosis. Also promotes apoptosis of I1 pharyngeal neuron sister cell. Together with eya- 1, required to specify the coelomocyte fate in embryonic and postembryonic precursors. Belongs to the SIX/Sine oculis homeobox family.
   
  
 0.643
hus-1
Checkpoint protein.
    
   0.582
ceh-48
One cut domain family member.
   
  
 0.576
mls-2
Homeobox domain-containing protein.
   
  
 0.571
nhr-2
Nuclear hormone receptor family member nhr-2; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
    
 
 0.557
imb-3
Importin N-terminal domain-containing protein.
      
 0.556
fkh-7
Fork-head domain-containing protein.
      
 0.555
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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