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dcr-1 protein (Caenorhabditis elegans) - STRING interaction network
"dcr-1" - Endoribonuclease dcr-1 in Caenorhabditis elegans
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dcr-1Endoribonuclease dcr-1; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (1910 aa)    
Predicted Functional Partners:
rde-1
RNA interference promoting factor RDE-1; Protein RDE-1 (rde-1) mRNA, complete cds (1020 aa)
     
 
  0.983
alg-1
Protein ALG-1, isoform a (alg-1) mRNA, complete cds; Belongs to the argonaute family (1023 aa)
     
 
  0.981
alg-2
Protein ALG-2, isoform a (alg-2) mRNA, complete cds; Belongs to the argonaute family (910 aa)
     
 
  0.980
eri-1
3’-5’ exonuclease eri-1; RNA exonuclease that acts as a negative regulator of RNA interference (RNAi). Probably acts by degrading the 3’-overhangs of short interfering RNAs (siRNAs). Its tissue specificity may help explain the inefficiency of neuronal RNAi (582 aa)
     
 
  0.962
rde-4
RNA interference promoting factor; Protein RDE-4 (rde-4) mRNA, complete cds (385 aa)
       
 
  0.960
pash-1
annotation not available (751 aa)
     
 
  0.959
rrf-3
RNA-dependent RNA polymerase Family; Protein RRF-3 (rrf-3) mRNA, complete cds (1765 aa)
     
 
  0.955
stau-1
STAUfen (DsRNA binding protein) homolog; Protein STAU-1 (stau-1) mRNA, complete cds (705 aa)
       
 
  0.946
E01A2.2
Serrate RNA effector molecule homolog; Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) (712 aa)
     
 
  0.922
lin-41
Protein lin-41; Heterochronic protein which acts downstream let-7 in temporal patterning. Represses lin-29 during late larval stages, which prevents terminal differentiation of hypodermal seam cells and promotes their division. Also governs the timing and extent of male tail tip morphogenesis. Involved in post-transcriptional gene regulation, uses two independent pathways. Has direct and specific RNA-binding activity and, depending on the location (5’UTR or 3’UTR) of the target site, triggers either mRNA decay or repression of translation; Belongs to the TRIM/RBCC family (1147 aa)
     
 
  0.916
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
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