node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ckr-1 | egl-30 | T23B3.4.1 | M01D7.7a.1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Heterotrimeric G protein alpha subunit. | 0.975 |
ckr-1 | gpb-1 | T23B3.4.1 | F13D12.7a.1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.446 |
ckr-1 | gpb-2 | T23B3.4.1 | F52A8.2a.1 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.446 |
egl-30 | ckr-1 | M01D7.7a.1 | T23B3.4.1 | Heterotrimeric G protein alpha subunit. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.975 |
egl-30 | egl-8 | M01D7.7a.1 | B0348.4d.1 | Heterotrimeric G protein alpha subunit. | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | 0.996 |
egl-30 | gar-2 | M01D7.7a.1 | F47D12.1c.1 | Heterotrimeric G protein alpha subunit. | Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] | 0.941 |
egl-30 | gar-3 | M01D7.7a.1 | Y40H4A.1b.1 | Heterotrimeric G protein alpha subunit. | Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. | 0.965 |
egl-30 | gpb-1 | M01D7.7a.1 | F13D12.7a.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.991 |
egl-30 | gpb-2 | M01D7.7a.1 | F52A8.2a.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.986 |
egl-30 | gpc-1 | M01D7.7a.1 | K02A4.2.3 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.978 |
egl-30 | gpc-2 | M01D7.7a.1 | F08B6.2.1 | Heterotrimeric G protein alpha subunit. | G protein gamma domain-containing protein. | 0.966 |
egl-30 | ser-1 | M01D7.7a.1 | F59C12.2a.1 | Heterotrimeric G protein alpha subunit. | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. | 0.969 |
egl-30 | unc-73 | M01D7.7a.1 | F55C7.7a.1 | Heterotrimeric G protein alpha subunit. | Guanine nucleotide exchange factor UNC-73A. | 0.935 |
egl-8 | egl-30 | B0348.4d.1 | M01D7.7a.1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | Heterotrimeric G protein alpha subunit. | 0.996 |
egl-8 | gar-3 | B0348.4d.1 | Y40H4A.1b.1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. | 0.466 |
egl-8 | gpb-2 | B0348.4d.1 | F52A8.2a.1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | Guanine nucleotide-binding protein subunit beta-2; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. | 0.596 |
egl-8 | unc-73 | B0348.4d.1 | F55C7.7a.1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...] | Guanine nucleotide exchange factor UNC-73A. | 0.671 |
gar-2 | egl-30 | F47D12.1c.1 | M01D7.7a.1 | Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] | Heterotrimeric G protein alpha subunit. | 0.941 |
gar-2 | gar-3 | F47D12.1c.1 | Y40H4A.1b.1 | Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] | Muscarinic acetylcholine receptor gar-3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Enhances the release of the neurotransmitter acetlycholine in cholinergic motor neurons, which in turn positively feeds back to depolarize body wall muscles and allows for the maintenance of normal body posture and locomotion. | 0.945 |
gar-2 | gpb-1 | F47D12.1c.1 | F13D12.7a.1 | Muscarinic acetylcholine receptor gar-2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover (By similarity). Regulates the activity of ventral cord motor neurons. Couples to the G(o) alpha G-protein subunit goa-1 to negatively regulate cholinergic receptor activity in the presence of high levels of the neurotransmitter acetylcholine in ventral cord motor neurons. As acetylcholin [...] | Guanine nucleotide-binding protein subunit beta-1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. In the early embryo, controls the magnitude of the forces acting on centrosomes but is not required for generating asymmetric forces. | 0.605 |