node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
aap-1 | ced-2 | Y110A7A.10.1 | Y41D4B.13a.1 | Phosphoinositide 3-kinase adapter subunit. | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | 0.552 |
aap-1 | let-23 | Y110A7A.10.1 | ZK1067.1d.1 | Phosphoinositide 3-kinase adapter subunit. | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | 0.769 |
aap-1 | nipi-4 | Y110A7A.10.1 | F40A3.5.1 | Phosphoinositide 3-kinase adapter subunit. | Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.499 |
aap-1 | sem-5 | Y110A7A.10.1 | C14F5.5.1 | Phosphoinositide 3-kinase adapter subunit. | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.958 |
aap-1 | sli-1 | Y110A7A.10.1 | M02A10.3a.1 | Phosphoinositide 3-kinase adapter subunit. | Suppressor of LIneage defect. | 0.886 |
cdap-2 | ehs-1 | Y44E3A.4.1 | ZK1248.3a.1 | CD2AP homolog. | Eps15 (Endocytosis protein) Homologous Sequence. | 0.541 |
cdap-2 | epn-1 | Y44E3A.4.1 | T04C10.2b.1 | CD2AP homolog. | ENTH domain-containing protein. | 0.507 |
cdap-2 | let-23 | Y44E3A.4.1 | ZK1067.1d.1 | CD2AP homolog. | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | 0.698 |
cdap-2 | sem-5 | Y44E3A.4.1 | C14F5.5.1 | CD2AP homolog. | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.637 |
cdap-2 | sli-1 | Y44E3A.4.1 | M02A10.3a.1 | CD2AP homolog. | Suppressor of LIneage defect. | 0.961 |
cdap-2 | ubq-2 | Y44E3A.4.1 | ZK1010.1.1 | CD2AP homolog. | Ubiquitin-60S ribosomal protein L40; [Ubiquitin]: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is invol [...] | 0.812 |
ced-2 | aap-1 | Y41D4B.13a.1 | Y110A7A.10.1 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | Phosphoinositide 3-kinase adapter subunit. | 0.552 |
ced-2 | let-23 | Y41D4B.13a.1 | ZK1067.1d.1 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | 0.956 |
ced-2 | nipi-4 | Y41D4B.13a.1 | F40A3.5.1 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.726 |
ced-2 | sem-5 | Y41D4B.13a.1 | C14F5.5.1 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.855 |
ced-2 | sli-1 | Y41D4B.13a.1 | M02A10.3a.1 | Cell death abnormality protein 2; Required for cell migration and engulfment of cell corpses but not for programmed cell death/apoptosis. Has a role in the migration of the 2 gonadal distal tip cells (DTCs). | Suppressor of LIneage defect. | 0.981 |
ehs-1 | cdap-2 | ZK1248.3a.1 | Y44E3A.4.1 | Eps15 (Endocytosis protein) Homologous Sequence. | CD2AP homolog. | 0.541 |
ehs-1 | epn-1 | ZK1248.3a.1 | T04C10.2b.1 | Eps15 (Endocytosis protein) Homologous Sequence. | ENTH domain-containing protein. | 0.990 |
ehs-1 | let-23 | ZK1248.3a.1 | ZK1067.1d.1 | Eps15 (Endocytosis protein) Homologous Sequence. | Receptor tyrosine-protein kinase let-23; Tyrosine-protein kinase receptor which, upon binding ligand lin-3, activates 2 signaling cascades: the let-60/Ras and MAP kinase signaling pathway and the let-60-independent phospholipase C-mediated Ca(2+) signaling pathway. Each pathway regulates distinct functions. By activating let-60/Ras, regulates larval development, induction of vulva cell precursors during vulva development, male spicule formation and posterior development of the epidermis. Probably by activating phospholipase plc-3 and inositol 1,4,5-trisphosphate receptor itr-1 signalin [...] | 0.946 |
ehs-1 | sem-5 | ZK1248.3a.1 | C14F5.5.1 | Eps15 (Endocytosis protein) Homologous Sequence. | Sex muscle abnormal protein 5; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases such as egl-15 and let-23 probably acting upstream of let-60/ras. Negatively regulates vulva induction probably downstream of let-23. Involved in sex myoblast migration. Negatively regulates fluid homeostasis probably downstream of egl-15. During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles probably downstream of egl- 15. Involved in cytoskeleton dynamics and is recruited by mig-13 to the [...] | 0.867 |