node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dab-1 | efn-2 | M110.5b.2 | C43F9.8.1 | PID domain-containing protein. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.400 |
dab-1 | vab-1 | M110.5b.2 | M03A1.1b.1 | PID domain-containing protein. | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.804 |
daf-18 | vab-1 | T07A9.6.1 | M03A1.1b.1 | Abnormal dauer formation protein 18; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3 antagonizes PtdIns(3,4,5)P3 production by age-1/PI3K and thus, negatively regulates daf-2-mediated processes including dauer formation, longevity, fat metabolism, chemotaxis towards salt, thermotolerance and axon guidance. Similarly, [...] | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.906 |
efn-2 | dab-1 | C43F9.8.1 | M110.5b.2 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | PID domain-containing protein. | 0.400 |
efn-2 | efn-3 | C43F9.8.1 | F15A2.5.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.564 |
efn-2 | efn-4 | C43F9.8.1 | F56A11.3.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | 0.607 |
efn-2 | mab-20 | C43F9.8.1 | Y71G12B.20a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] | 0.684 |
efn-2 | sax-3 | C43F9.8.1 | ZK377.2b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. | 0.528 |
efn-2 | unc-6 | C43F9.8.1 | F41C6.1.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Netrin unc-6; Component of an extracellular matrix cue that guides dorsoventral migrations on the epidermis. Required for the guidance of pioneer axons and migrating cells along the body wall. During gonad morphogenesis, involved in distal tip cell (DTC) migration from the dorsal side of the hermaphrodite body to the midbody to allow for formation of gonad arms. Its association with either unc-40 or unc-5 receptors will lead to axon attraction or repulsion, respectively. Involved in the positioning of ray 1, the most anterior ray sensilium, in the male tail. Required for the formation [...] | 0.446 |
efn-2 | vab-1 | C43F9.8.1 | M03A1.1b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.979 |
efn-2 | vab-2 | C43F9.8.1 | Y37E11AR.6a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.595 |
efn-3 | efn-2 | F15A2.5.1 | C43F9.8.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.564 |
efn-3 | efn-4 | F15A2.5.1 | F56A11.3.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | 0.614 |
efn-3 | mab-20 | F15A2.5.1 | Y71G12B.20a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Semaphorin-2A; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, required for proper ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting and allows the formation of distinct sensory rays. Seems to control cell-cell contact formation through 2 parallel pathways, one involving efn-4 and one involving plx-2 and unc-129. Involved in axon guidance. Probably by binding receptor plx-2, regulates fln-1-mediated remodeling of the actin cytoskeleton and thus [...] | 0.718 |
efn-3 | sax-3 | F15A2.5.1 | ZK377.2b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Protein sax-3; Required to confine migrating sex myoblasts to the ventral muscle quadrants during their migration through the body and for multiple aspects of sensory, motor, and interneuron axon guidance. Belongs to the immunoglobulin superfamily. ROBO/SAX3 family. | 0.618 |
efn-3 | vab-1 | F15A2.5.1 | M03A1.1b.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin receptor 1; Receptor for members of the ephrin family (By similarity). Receptor for major sperm proteins (MSPs), that functions as sperm- sensing checkpoint which inhibits oocyte meiotic maturation and ovulation when sperm are not available for fertilization. Specifically, functions to negatively regulates oocyte maturation and MAPK activation in the absence of MSPs. Required for the MSP-mediated increase in the basal sheath cell contraction rate in somatic cells. Phosphorylates phosphatase daf-18/PTEN which probably promotes daf-18 degradation. By inactivating daf-18, regulates [...] | 0.980 |
efn-3 | vab-2 | F15A2.5.1 | Y37E11AR.6a.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.604 |
efn-3 | vpr-1 | F15A2.5.1 | F33D11.11.1 | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | Major sperm protein; Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod. | 0.532 |
efn-4 | efn-2 | F56A11.3.1 | C43F9.8.1 | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.607 |
efn-4 | efn-3 | F56A11.3.1 | F15A2.5.1 | Ephrin-4; Regulates the formation or stabilization of cell-cell contacts at several stages of epithelial morphogenesis. In early embryonic development, involved in ventral closure of the epidermis. During male tail morphogenesis, regulates precursor cell sorting together with mab-20 and allows the formation of distinct sensory rays. Probably acts as a ligand for lad-2 to regulate axon guidance of several neurons including SDQL, SDQR, SMD and PLN neurons during neurogenesis. | Ephrin RBD domain-containing protein; Belongs to the ephrin family. | 0.614 |