Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| chd-3 | let-418 | T14G8.1.1 | F26F12.7.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | 0.864 |
| chd-3 | mep-1 | T14G8.1.1 | M04B2.1.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | 0.675 |
| chd-3 | spr-5 | T14G8.1.1 | Y40B1B.6.1 | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.650 |
| cyn-4 | mep-1 | F59E10.2.1 | M04B2.1.1 | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | 0.674 |
| cyn-4 | mog-3 | F59E10.2.1 | F52C9.7.2 | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. | Sex determining protein MOG-3. | 0.956 |
| cyn-4 | mog-4 | F59E10.2.1 | C04H5.6a.1 | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. | Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-4; ATP-binding RNA helicase involved in pre-mRNA splicing (Probable). Operates during embryogenesis. | 0.830 |
| let-418 | chd-3 | F26F12.7.1 | T14G8.1.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | 0.864 |
| let-418 | lin-1 | F26F12.7.1 | C37F5.1a.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | ETS domain-containing protein. | 0.950 |
| let-418 | lin-13 | F26F12.7.1 | C03B8.4.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. | 0.788 |
| let-418 | mep-1 | F26F12.7.1 | M04B2.1.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | 0.966 |
| let-418 | mes-4 | F26F12.7.1 | Y2H9A.1.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] | 0.719 |
| let-418 | pie-1 | F26F12.7.1 | Y49E10.14a.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | Pharynx and intestine in excess protein 1; Maternally provided PIE-1 is required for germline cell fate determination. Functions as a repressor of RNA polymerase II-dependent gene expression in the developing germline. Required for expression of nos-2 in P4 germline blastomere cells. Inhibits the histone deacetylase activity of hda-1. Represses transcriptional activation of cdk-9 and cit-1.1, which are members of the P-TEFb complex. | 0.592 |
| let-418 | spr-5 | F26F12.7.1 | Y40B1B.6.1 | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...] | 0.887 |
| lin-1 | let-418 | C37F5.1a.1 | F26F12.7.1 | ETS domain-containing protein. | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | 0.950 |
| lin-1 | mep-1 | C37F5.1a.1 | M04B2.1.1 | ETS domain-containing protein. | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | 0.763 |
| lin-13 | let-418 | C03B8.4.1 | F26F12.7.1 | Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. | Protein let-418; Part of a NuRD (Nucleosome Remodeling and Deacetylase) complex which is implicated in the synMuv B pathway that negatively regulates specification of vulval cell fate. This negative regulation is thought to be mediated via interaction with the promoter of lin-39, a key regulator in vulva development, and is dependent on the presence lin-1. Contributes to negative regulation of lag-2 which is expressed in the gut during larval development. Has a broad role in development. In association with akir-1, plays a role in regulating the transcription of antimicrobial peptide g [...] | 0.788 |
| lin-13 | mep-1 | C03B8.4.1 | M04B2.1.1 | Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | 0.787 |
| lin-13 | mes-4 | C03B8.4.1 | Y2H9A.1.1 | Zinc finger protein lin-13; Involved in repression of vulval fate, possibly by a tumor suppressor protein Rb-mediated mechanism. | Histone-lysine N-methyltransferase mes-4; Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys- 36' dimethylation until about the 40-cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes. Not related to transcription elongation. Required for small-RNA-induced H3K27 trimethylation. May suppress sensitivity to [...] | 0.610 |
| mep-1 | chd-3 | M04B2.1.1 | T14G8.1.1 | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | Chromodomain-helicase-DNA-binding protein 3 homolog; Chromatin-remodeling protein that has a role in notch signaling-dependent vulval cell fate determination. May also have a role in pharyngeal precursor cell specification. | 0.675 |
| mep-1 | cyn-4 | M04B2.1.1 | F59E10.2.1 | MOG interacting and ectopic P-granules protein 1; Has a broad role in development, specifically in the genetic pathway SynMuvB that negatively regulates specification of the vulval cell fate. Required for fem-3 3'-UTR-mediated repression in the regulation of the sperm/oocyte switch. Acts by regulating the translation of fem-3 mRNA, by binding to its 3'-UTR. | Peptidyl-prolyl cis-trans isomerase 4; May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins. Influences the hermaphrodite switch from spermatogenesis to oogenesis. Required for body wall muscle cell development. | 0.674 |
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