STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
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Experiments
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[Homology]
Score
mig-22Chondroitin sulfate synthase mig-22; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP- GalNAc to the non-reducing end of the elongating chondroitin polymer (By similarity). Required together with sqv-5 for the biosynthesis of chondroitin. Chondroitin is involved in organogenesis of the vulva, maturation of the gonad, and neural development. May have a specific role in unc- 6/netrin-mediated dorsal guidance of gonadal distal tip cells. Glycosyltransfera [...] (804 aa)    
Predicted Functional Partners:
sqv-5
Chondroitin sulfate synthase sqv-5; Has both beta-1,3-glucuronic acid and beta-1,4-N- acetylgalactosamine transferase activity. The beta- 1,3-glucuronic acid transferase activity is controversial as it is not detected using the purified recombinant enzyme. Adds the first N-acetylgalactosamine(GalNAc) to initiate the chondroitin chain. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and GalNAc from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Together with mig-22, required for chondroitin synthesis. Plays a role in early embryonic development by controlling [...]
  
0.973
chst-1
Carbohydrate sulfotransferase chst-1; Catalyzes the transfer of sulfate to position 4 of non- reducing N-acetylgalactosamine (GalNAc) residue of chondroitin.
      
 0.851
sqv-8
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8; Glycosyltransferase required for the biosynthesis of the tetrasaccharide (GlcA-Gal-Gal-Xyl-)Ser core linker of heparan sulfate and chondroitin sulfate. May be involved in the biosynthesis of the HNK-1 carbohydrate epitope on glycoproteins. Required for embryonic development. Involved in the elongation of the pharyngeal isthmus during the later stages of embryonic development. Involved in vulval epithelium invagination.
   
  
 0.800
rib-2
Exostosin-2 homolog; Glycosyltransferase required for the biosynthesis of heparan sulfate. Initiates heparan sulfate synthesis by transferring GlcNAc to the (GlcA-Gal-Gal- Xyl-)Ser core linker (GlcNAcT-I activity). In association with rib-1, is also responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains (GlcNAcT-II and GlcAT-II activities). Required for normal ventral epidermal enclosure during the early stages of embryonic development. In addition, involved in the elon [...]
   
  
 0.751
cogc-3
Conserved Oligomeric Golgi (COG) Component.
   
  
 0.703
sdn-1
Probable syndecan; Cell surface proteoglycan that bears heparan sulfate (By similarity). Required for correct mitotic spindle orientation of the ABar blastomere division plane and this may be through modulation of astral microtubule array, and in association with the wnt-signaling proteins mig-5 and dsh-2. Involved in the migration of AQR and PQR neurons, which descend from the Q neuroblasts. Promotes the axon guidance of D-type motor neurons.
      
 0.702
cogc-1
Conserved Oligomeric Golgi (COG) Component.
   
  
 0.702
mig-23
Nucleoside-diphosphatase mig-23; Seems to be able to hydrolyze ADP, UDP and GDP. Supports mig- 17 glycosylation and surface expression, which is required for proper migration of distal tip cells during gonad morphogenesis.
   
  
 0.698
mig-18
Abnormal cell migration protein 18; Required for the directional control of distal tip cell migration during gonadogenesis, probably by recruiting fibulin fbl-1 to the gonad basement membrane.
      
 0.690
Y47D9A.1
NTP_transferase domain-containing protein.
   
  
 0.568
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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