STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpx-7Glutathione peroxidase; Belongs to the glutathione peroxidase family. (197 aa)    
Predicted Functional Partners:
prdx-6
Thioredoxin domain-containing protein.
   
 0.959
gsr-1
Glutathione reductase, mitochondrial; Maintains high levels of reduced glutathione in the cytosol. Involved in resistance to oxidative stress and starvation. Together with thioredoxin reductase txtr- 1, required for the reduction of disulfide groups in the cuticle during molting.
  
 
 0.952
gpx-5
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
  
 
0.921
gpx-3
Glutathione peroxidase 3; Belongs to the glutathione peroxidase family.
  
  
0.917
gss-1
Glutathione synthetase.
   
 
 0.912
gpx-1
Glutathione peroxidase 1; May constitute a glutathione peroxidase-like protective system against oxidative stresses.
  
  
0.904
gpx-2
Glutathione peroxidase 2; May constitute a glutathione peroxidase-like protective system against oxidative stresses.
  
  
0.904
txdc-12.1
Thioredoxin domain-containing protein.
   
 0.904
F22F7.7
Gamma-glutamylcyclotransferase; Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides; Belongs to the gamma-glutamylcyclotransferase family.
     
 0.902
gst-4
Glutathione S-transferase 4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection.
   
 
 0.822
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.