STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
unc-7Innexin unc-7; Structural component of the gap junctions (By similarity). Required for coordinated locomotion. Probably by regulating neuronal transmission downstream of lin-3 and receptor lin- 23 and phospholipase plc-3 in ALA neurons, involved in the decrease in pharyngeal pumping during the quiescent state that precedes each larval molt. (546 aa)    
Predicted Functional Partners:
unc-79
Uncoordinated protein 79.
   
  
 0.874
unc-1
Protein unc-1.
   
  
 0.845
avr-14
Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.755
unc-80
Protein unc-80; Probable component of the nca-1 sodium channel complex, a cation channel that regulates neuronal activity by transmitting depolarization signals to synapses. Regulates the transition from slow to rapid forms of locomotion. Required for localization of nca-1 along axons and in non-synaptic regions. Contributes to endocytosis defects in synaptojanin mutants. Involved in the control of anasthetic response to halothane.
   
 
 0.718
glc-4
Glutamate-gated ChLoride channel; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.687
nca-2
Four domain-type voltage-gated ion channel alpha-1 subunit.
   
  
 0.684
avr-15
Neur_chan_memb domain-containing protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family.
   
  
 0.677
sto-6
PHB domain-containing protein.
   
  
 0.661
sto-5
PHB domain-containing protein.
   
  
 0.644
unc-9
Innexin unc-9; Structural component of the gap junctions. Belongs to the pannexin family.
  
 
0.644
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.