node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F25B5.3 | F32D1.5 | F25B5.3b.1 | F32D1.5a.1 | Putative cytosolic 5'-nucleotidase 3. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.901 |
F25B5.3 | R07H5.8 | F25B5.3b.1 | R07H5.8.1 | Putative cytosolic 5'-nucleotidase 3. | PfkB domain-containing protein. | 0.908 |
F25B5.3 | ZK673.2 | F25B5.3b.1 | ZK673.2.1 | Putative cytosolic 5'-nucleotidase 3. | Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family. | 0.905 |
F25B5.3 | adsl-1 | F25B5.3b.1 | R06C7.5a.2 | Putative cytosolic 5'-nucleotidase 3. | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. | 0.902 |
F25B5.3 | ampd-1 | F25B5.3b.1 | C34F11.3d.1 | Putative cytosolic 5'-nucleotidase 3. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.918 |
F25B5.3 | let-754 | F25B5.3b.1 | C29E4.8.2 | Putative cytosolic 5'-nucleotidase 3. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.912 |
F25B5.3 | pde-2 | F25B5.3b.1 | R08D7.6a.1 | Putative cytosolic 5'-nucleotidase 3. | Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. | 0.910 |
F32D1.5 | F25B5.3 | F32D1.5a.1 | F25B5.3b.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Putative cytosolic 5'-nucleotidase 3. | 0.901 |
F32D1.5 | R07H5.8 | F32D1.5a.1 | R07H5.8.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | PfkB domain-containing protein. | 0.466 |
F32D1.5 | adsl-1 | F32D1.5a.1 | R06C7.5a.2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. | 0.951 |
F32D1.5 | ampd-1 | F32D1.5a.1 | C34F11.3d.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.970 |
F32D1.5 | pde-2 | F32D1.5a.1 | R08D7.6a.1 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. | 0.943 |
R07H5.8 | F25B5.3 | R07H5.8.1 | F25B5.3b.1 | PfkB domain-containing protein. | Putative cytosolic 5'-nucleotidase 3. | 0.908 |
R07H5.8 | F32D1.5 | R07H5.8.1 | F32D1.5a.1 | PfkB domain-containing protein. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.466 |
R07H5.8 | ZK673.2 | R07H5.8.1 | ZK673.2.1 | PfkB domain-containing protein. | Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family. | 0.957 |
R07H5.8 | adsl-1 | R07H5.8.1 | R06C7.5a.2 | PfkB domain-containing protein. | Adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. | 0.976 |
R07H5.8 | ampd-1 | R07H5.8.1 | C34F11.3d.1 | PfkB domain-containing protein. | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. | 0.985 |
R07H5.8 | let-754 | R07H5.8.1 | C29E4.8.2 | PfkB domain-containing protein. | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. | 0.984 |
R07H5.8 | pde-2 | R07H5.8.1 | R08D7.6a.1 | PfkB domain-containing protein. | Probable 3',5'-cyclic phosphodiesterase pde-2; May negatively regulate the activity of cGMP-dependent protein kinase egl-4 which in turn controls body size. | 0.918 |
ZK673.2 | F25B5.3 | ZK673.2.1 | F25B5.3b.1 | Probable adenylate kinase isoenzyme ZK673.2; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Belongs to the adenylate kinase family. | Putative cytosolic 5'-nucleotidase 3. | 0.905 |