node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alh-13 | tap-1 | T22H6.2b.1 | C44H4.5.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. | 0.410 |
alh-13 | zak-1 | T22H6.2b.1 | R13F6.6c.1 | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | SAM domain-containing protein. | 0.516 |
dhhc-5 | zak-1 | R13F6.5.1 | R13F6.6c.1 | Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. | SAM domain-containing protein. | 0.772 |
mek-1 | sek-3 | K08A8.1a.1 | ZC449.3b.1 | Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.634 |
mek-1 | zak-1 | K08A8.1a.1 | R13F6.6c.1 | Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] | SAM domain-containing protein. | 0.943 |
mkk-4 | sek-3 | F42G10.2.1 | ZC449.3b.1 | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.910 |
mkk-4 | sek-6 | F42G10.2.1 | VZC374L.1.1 | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | Protein kinase domain-containing protein. | 0.901 |
mkk-4 | zak-1 | F42G10.2.1 | R13F6.6c.1 | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | SAM domain-containing protein. | 0.535 |
ptp-1 | zak-1 | C48D5.2a.2 | R13F6.6c.1 | Tyrosine-protein phosphatase 1. | SAM domain-containing protein. | 0.698 |
sek-3 | mek-1 | ZC449.3b.1 | K08A8.1a.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Dual specificity mitogen-activated protein kinase kinase mek-1; Dual specificity protein kinase which may phosphorylate kgb-1 and thereby is an essential component of the JNK pathway composed of mlk-1, mek-1 and kgb-1. May also have a synergistic role with sek-1 in phosphorylating pmk-1. Involved in the response to environmental stress including heavy metal ions (Cu(2+) and Cd(2+)), oxidative stress and starvation. In association with sek-1, regulates germline cell apoptosis in response to oxidative, osmotic and heat shock stresses. Involved in resistance to pathogenic bacteria infecti [...] | 0.634 |
sek-3 | mkk-4 | ZC449.3b.1 | F42G10.2.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.910 |
sek-3 | sek-6 | ZC449.3b.1 | VZC374L.1.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein. | 0.914 |
sek-3 | zak-1 | ZC449.3b.1 | R13F6.6c.1 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | SAM domain-containing protein. | 0.547 |
sek-6 | mkk-4 | VZC374L.1.1 | F42G10.2.1 | Protein kinase domain-containing protein. | MAP kinase kinase mkk-4; Activity is required in presynaptic neurons, in a dose- dependent manner, for normal presynaptic development and morphology. Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord. | 0.901 |
sek-6 | sek-3 | VZC374L.1.1 | ZC449.3b.1 | Protein kinase domain-containing protein. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.914 |
sek-6 | zak-1 | VZC374L.1.1 | R13F6.6c.1 | Protein kinase domain-containing protein. | SAM domain-containing protein. | 0.542 |
tap-1 | alh-13 | C44H4.5.1 | T22H6.2b.1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. | Probable delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.410 |
tap-1 | tol-1 | C44H4.5.1 | C07F11.1.1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. | TIR domain-containing protein. | 0.656 |
tap-1 | ubc-13 | C44H4.5.1 | Y54G2A.31.1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. | Ubiquitin-conjugating enzyme E2 13; Involved in protein ubiquitination, but has no ubiquitin ligase activity on its own. The uev-1-ubc-13 heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. Involved in sorting Lys-63-linked polyubiquitinated maternal membrane proteins for degradation by targeting to multivesicular bodies. May be involved in the ubiquitination and growth of intracellular polyglutamine protein aggregates. May have a role in AMPA-type glutamate receptor trafficking in neurons. | 0.774 |
tap-1 | zak-1 | C44H4.5.1 | R13F6.6c.1 | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. | SAM domain-containing protein. | 0.739 |