STRINGSTRING
pdha-1 protein (Caenorhabditis elegans) - STRING interaction network
"pdha-1" - Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial in Caenorhabditis elegans
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdha-1Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components- pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (414 aa)    
Predicted Functional Partners:
pdhb-1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components- pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) (352 aa)
 
  0.999
dlat-1
Protein DLAT-1 (dlat-1) mRNA, complete cds; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components- pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (507 aa)
   
  0.999
dld-1
Dihydrolipoyl dehydrogenase, mitochondrial; Protein DLD-1, isoform a (495 aa)
     
  0.999
C30H6.7
DihydroLipoyllysine-residue AcetylTransferase; Protein C30H6.7, isoform a (C30H6.7) mRNA, complete cds (337 aa)
   
  0.998
tag-173
Branched Chain Keto acid Dehydrogenase e1 (E1) subunit; Protein TAG-173 (tag-173) mRNA, complete cds (366 aa)
 
  0.996
pdp-1
Pyruvate Dehydrogenase Phosphatase homolog; Protein PDP-1 (pdp-1) mRNA, complete cds (451 aa)
   
  0.995
ogdh-1
2-oxoglutarate dehydrogenase, mitochondrial; The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components- 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity) (1029 aa)
     
  0.995
pdhk-2
Probable [pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial; Inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (401 aa)
   
  0.995
ldh-1
L-lactate dehydrogenase; Protein LDH-1 (ldh-1) mRNA, complete cds; Belongs to the LDH/MDH superfamily. LDH family (333 aa)
   
  0.973
pyc-1
Pyruvate carboxylase 1; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (1175 aa)
   
 
  0.972
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Caenorhabditis elegans, Rhabditis elegans, roundworm
Server load: low (5%) [HD]