STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gpcp-2Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 2. (796 aa)    
Predicted Functional Partners:
cha-1
Choline O-acetyltransferase; Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses (By similarity). Required in SIA sublateral cholinergic motor neurons for a left-right turning behavior that occurs during the lethargus phase of the normal sleep process called 'flipping'. During 'flipping' animals rotate 180 degrees about their longitudinal axis ; Belongs to the carnitine/choline acetyltransferase family.
   
 
 0.974
ath-1
Abhydrolase_2 domain-containing protein.
    
 0.947
ZK370.4
Uncharacterized NTE family protein ZK370.4; Belongs to the NTE family.
  
 
 0.937
gpcp-1
Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 1.
  
  
0.916
ckb-3
Putative choline kinase B3; Belongs to the choline/ethanolamine kinase family.
    
 0.910
ckb-1
Choline kinase B1; Belongs to the choline/ethanolamine kinase family.
    
 0.910
ckb-2
Choline kinase B2; Catalyzes the first step in phosphatidylcholine biosynthesis. Phosphorylates choline.
    
 0.910
cka-2
Choline kinase A2; Catalyzes the first step in phosphatidylcholine biosynthesis. May contribute to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine but the activity is much higher with choline. Belongs to the choline/ethanolamine kinase family.
    
 0.910
ace-1
Acetylcholinesterase 1; Rapidly hydrolyzes choline released into the synapse. It can hydrolyze butyrylthiocholine.
     
 0.906
ace-2
Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family.
     
 0.906
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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