STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcy-31Soluble guanylate cyclase gcy-31; Synthesizes cyclic GMP (cGMP) from GTP. May play a role in embryogenesis. (702 aa)    
Predicted Functional Partners:
gcy-33
Soluble guanylate cyclase gcy-33; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.810
flp-17
FMRF-Like Peptide.
      
 0.758
tax-4
Cyclic nucleotide-gated cation channel; Required for normal thermosensation and chemosensation sensory behavior. Required, downstream of receptor- type guanylate cyclase gcy-9, for CO2-mediated responses in BAG neurons. Required, downstream of receptor-type guanylate cyclase gcy-14, for alkaline pH-mediated responses in ASE-left (ASEL) neurons. Involved in the development of ASJ sensory neuron axon during late larval stages and in the maintenance of normal axon morphology in the adult. Regulates dauer formation. Required for the calcium flux to the cytoplasm in the ASJ sensory neurons [...]
   
 
 0.741
gcy-34
Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
 
0.720
tax-2
Cyclic nucleotide-binding domain-containing protein.
   
 
 0.715
gcy-37
Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.707
gcy-36
Soluble guanylate cyclase gcy-36; Plays a central role in social feeding behavior by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which probably binds to its heme-binding sites, may regulate social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in avoidance of hyper [...]
  
  
0.703
gcy-32
Soluble guanylate cyclase gcy-32; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). Influences aerotaxis responses, aggregation and bordering behaviors (gathering around the edge of a bacterial lawn) in combination with other soluble guanylate cyclases.
  
 
0.695
gcy-35
Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...]
  
  
0.693
F54D5.7
Probable glutaryl-CoA dehydrogenase, mitochondrial.
      
 0.669
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (30%) [HD]