STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cec-3Chromo domain-containing protein cec-3; Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me), with highest preference for trimethylated 'Lys-9' (H3K9me3) followed by dimethylated 'Lys-9' (H3K9me2) followed by monomethylated 'Lys-9' (H3K9me1). Plays a role in maintaining correct unc-4 expression in the VC motor neurons where unc- 4 is expressed in the vulval but not in the non-vulval VC neurons. (339 aa)    
Predicted Functional Partners:
cec-6
Chromo domain-containing protein.
   
  
 0.824
set-25
Histone-lysine N-methyltransferase set-25; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using mono- and dimethylated H3 'Lys-9' as substrate. Acts redundantly with the methyltransferase met-2 to position chromosome arms at the nuclear lamina. Required for small-RNA-induced H3K9 methylation. Together with met-2, protects and stabilizes repeat-rich genomic regions by suppressing transcription- induced replication stress through methylation of H3K9.
   
 
 0.811
lin-61
Protein lin-61; Synthetic multivulva class B (synMuvB) protein required to repress the induction of vulval development by Ras signaling. Unlike other synMuv proteins it does not associate with the multiprotein DRM complex and the NuRD-like complex. Interaction with methylated histone H3 is essential for vulva development. It has a role in maintaining genome stability.
   
 
 0.773
spr-5
Probable lysine-specific histone demethylase 1; Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3 (By similarity). Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together wi [...]
   
 
 0.761
cec-4
Chromo domain-containing protein cec-4; Chromatin anchor protein which binds to methylated lysine residues on histone H3, thereby recruiting heterochromatin to the nuclear periphery. May be required for the correct positioning of chromatin and nucleoli in embryos.
   
  
 0.757
cec-1
Chromo domain-containing protein cec-1.
    
 
 0.747
jmjd-2
Lysine-specific demethylase 4; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. Involved in the negative regulation of lifespan in a germline-dependent fashion.
   
 
 0.742
cec-2
Chromo domain-containing protein.
   
  
 0.707
hpl-1
Heterochromatin protein 1 homolog.
      
 0.700
nra-3
PHD-type domain-containing protein.
   
  
 0.698
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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