STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
esyt-2C2 domain-containing protein. (713 aa)    
Predicted Functional Partners:
mctp-1
Multiple C2 and Transmembrane region Protein family homolog.
      
 0.832
gop-2
GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.
 
      0.807
gop-1
Protein CLEC16A homolog; Regulator of mitophagy.
 
 
    0.750
idi-1
Nudix hydrolase domain-containing protein.
      
 0.740
rab-3
Ras-related protein Rab-3; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity). Plays a role in the recruitment of endophilin unc-57 to synaptic vesicles. Probably by controlling dense-core vesicle trafficking, plays a role in the AVG neuron-mediated formation of the right axon tract of the ventral nerve cord. Belongs to the small GTPase superfamily. Rab family.
   
 
 0.687
zfp-2
Zinc finger protein zfp-2; Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.
      
 0.665
prmt-6
Methyltransf_25 domain-containing protein.
   
 
 0.641
vti-1
t-SNARE coiled-coil homology domain-containing protein.
      
 0.641
obr-1
Oxysterol-binding protein; Belongs to the OSBP family.
   
 
 0.627
T19C3.4
Uncharacterized protein T19C3.4.
   
 
 0.617
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.