STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
peb-1FLYWCH-type domain-containing protein. (427 aa)    
Predicted Functional Partners:
nhr-256
NR LBD domain-containing protein.
      
 0.811
nhr-283
Nuclear Hormone Receptor family.
      
 0.809
flh-2
FLYWCH-type domain-containing protein.
   
  
 0.761
flh-3
FLYWCH-type domain-containing protein.
      
 0.758
pha-4
Defective pharyngeal development protein 4; Acts as a transcription factor required for formation of the pharyngeal primordium. Binds to the consensus sequence 5'-T[AG]TT[TG][AG][TC]-3' with variations of the sequence affecting onset of target gene expression. Activates a wide array of pharyngeal genes including ceh-22 and myo-2 and represses ectodermal genes lin-26 and elt-3, ensuring pharyngeal cell fate. Required for recruitment of htz-1 to a subset of pharyngeal promoters to ensure gene activation and also acts synergistically with tbx-2 in pharyngeal development. Acts in the regul [...]
   
 
 0.740
ceh-28
NK-2 family homeodomain protein CEH-28.
    
 
 0.727
ceh-22
Homeobox protein ceh-22; Involved in combinatorial activation of gene expression in pharyngeal muscle. Specifically binds a site necessary for activity of the B subelement of myo-2 enhancer.
   
  
 0.719
nhr-127
Nuclear hormone receptor family member nhr-127; Orphan nuclear receptor; Belongs to the nuclear hormone receptor family.
   
  
 0.707
cky-1
BHLH-PAS factor.
   
  
 0.706
flh-1
FLYWCH-type domain-containing protein.
      
 0.698
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.