STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lin-32Protein lin-32; Essential for the specification of the neuroblast cell fate in the development of peripheral sense organs. Its role in the generation of sensory neurons may be through positively regulating the expression of the zinc finger protein ztf-11 during postdeirid neurogenesis. (142 aa)    
Predicted Functional Partners:
hlh-14
BHLH domain-containing protein.
  
 
 0.927
hlh-2
BHLH domain-containing protein.
   
 
 0.875
unc-86
Transcription factor unc-86; Transcription factor required for correct cell fate determination and differentiation in diverse neuronal cell lineages where it plays a role in specifying the fate of daughter cells during cell divisions. Involved in sensory neuron production and function. Binds both alone and with mec-3 to the mec-3 promoter to initiate and maintain mec-3 expression which is required for sensory neuron differentiation. In addition, binds both alone and with mec-3 to the promoters of mec-4 and mec-7 which act to regulate sensory neuron function. Involved in determining the [...]
  
  
 0.873
lin-22
BHLH domain-containing protein.
    
 
 0.852
hlh-16
BHLH domain-containing protein.
   
 
 0.820
mab-5
Homeobox protein mab-5; Transcription factor that binds to the promoter region of the transcription factor lin-39 to repress its expression in Q neuroblasts and thereby direct left Q neuroblast (QL) daughter cell migration. During postembryonic development, required for posterior-specific pattern formation. Within the posterior body region, controls epidermal, neuronal, and mesodermal cell differentiation. Belongs to the Antp homeobox family.
   
 
 0.779
vab-3
Homeobox domain-containing protein.
   
  
 0.760
vab-15
Homeobox protein vab-15; Probable transcription factor needed for the proper production of touch cell precursors. Essential for embryonic morphogenesis.
   
 
 0.734
ham-1
Stork_head domain-containing protein.
   
  
 0.732
egl-5
Homeobox protein egl-5; Essential for the determination of specific neurons.
   
 
 0.725
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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