STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pxf-1Rap guanine nucleotide exchange factor; Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. Belongs to the RAPGEF2 family. (1470 aa)    
Predicted Functional Partners:
let-60
Ras protein let-60; The level of let-60 controls the switch between vulval and hypodermal cell fates during C.elegans vulval induction. May stimulate the guanine nucleotide exchange factor (GEF) activity of rap-1. Belongs to the small GTPase superfamily. Ras family.
   
 0.963
ras-1
GTP binding protein.
   
 0.927
ras-2
GTP binding protein.
   
 0.927
ptp-1
Tyrosine-protein phosphatase 1.
    
 
 0.847
rap-2
RAP homolog (Vertebrate Rap GTPase family).
   
 
 0.808
smz-2
Sperm Meiosis PDZ domain containing proteins.
      
 0.806
smz-1
Sperm Meiosis PDZ domain containing proteins.
      
 0.804
rap-1
Ras-related protein Rap-1; Required in the hypodermis for proper formation of the cuticle; Belongs to the small GTPase superfamily. Ras family.
   
 
 0.802
gras-1
PDZ domain-containing protein.
   
  
 0.700
gipc-2
PDZ domain-containing protein.
      
 0.700
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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