STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hlb-1Liprin-beta homolog; Involved in the regulation of synaptic function at neuromuscular junctions. Together with the liprin- alpha protein syd-2, may play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. Does not seem to be required for neuronal development. May regulate the disassembly of focal adhesions (By similarity). Does not bind receptor-like tyrosine phosphatases type 2A (By similarity); Belongs to the liprin family. Liprin-beta subfamily. (1004 aa)    
Predicted Functional Partners:
syd-2
Liprin-alpha; May play a role in regulating the structure of the neuronal region, called the active zone, from which synaptic vesicles send neurotransmitter signals across the synapse. This may be in association with the liprin-beta protein hlb-1 ; Belongs to the liprin family. Liprin-alpha subfamily.
   
 
0.966
ptp-3
Tyrosine-protein phosphatase Lar-like; Has a role in early neural and epidermal development; neuroblast movements during closure of the gastrulation cleft and epidermal morphogenesis. Vab-1 and ptp-3 may function redundantly within the same sets of neuronal precursors.
   
 
 0.720
git-1
GIT1 (Mammalian G protein-coupled receptor kinase InTeractor 1) homolog.
      
 0.670
dct-6
Protein dct-6; May have a role in tumor suppression.
   
  
 0.670
fhod-1
Formin HOmology Domain.
   
  
 0.634
zoo-1
ZO-1 (Zonula Occludens tight junctional protein) Ortholog.
   
  
 0.599
cab-1
Protein cab-1.
   
  
 0.564
ampd-1
AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.
   
  
 0.563
T13H5.1
Tyrosine-protein phosphatase.
   
 
 0.562
spc-1
SPeCtrin.
   
  
 0.506
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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