node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C34B7.2 | mtm-1 | C34B7.2.1 | Y110A7A.5.1 | SAC domain-containing protein. | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.972 |
C34B7.2 | mtm-3 | C34B7.2.1 | T24A11.1a.1 | SAC domain-containing protein. | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. | 0.975 |
C34B7.2 | mtm-6 | C34B7.2.1 | F53A2.8b.2 | SAC domain-containing protein. | Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...] | 0.964 |
C34B7.2 | piki-1 | C34B7.2.1 | F39B1.1.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family. | 0.531 |
C34B7.2 | vps-34 | C34B7.2.1 | B0025.1a.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.955 |
W09C5.7 | Y75B8A.24 | W09C5.7a.1 | Y75B8A.24.1 | SAC domain-containing protein. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.910 |
W09C5.7 | aap-1 | W09C5.7a.1 | Y110A7A.10.1 | SAC domain-containing protein. | Phosphoinositide 3-kinase adapter subunit. | 0.903 |
W09C5.7 | mtm-1 | W09C5.7a.1 | Y110A7A.5.1 | SAC domain-containing protein. | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.903 |
W09C5.7 | mtm-3 | W09C5.7a.1 | T24A11.1a.1 | SAC domain-containing protein. | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. | 0.904 |
W09C5.7 | mtm-6 | W09C5.7a.1 | F53A2.8b.2 | SAC domain-containing protein. | Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...] | 0.905 |
W09C5.7 | piki-1 | W09C5.7a.1 | F39B1.1.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase piki-1; Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3- phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and rab-7. The first pulse is initiated by piki-1, then maintained by vps-34 which also produces the second pulse. Unlike vps-34, not involved in the formation of PI3P in early endosomes; Belongs to the PI3/PI4-kinase family. | 0.900 |
W09C5.7 | sac-1 | W09C5.7a.1 | F30A10.6.1 | SAC domain-containing protein. | SAC domain-containing protein. | 0.910 |
W09C5.7 | vps-34 | W09C5.7a.1 | B0025.1a.1 | SAC domain-containing protein. | Phosphatidylinositol 3-kinase catalytic subunit type 3; Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Together with bec-1, mediates the production of phosphatidylinositol 3-phosphate on intracellular vesicles and thereby regulates membrane trafficking. Plays a role in endosome-to-Golgi retrograde transport of mig-14. Involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recr [...] | 0.900 |
Y71H2AM.2 | aap-1 | Y71H2AM.2.1 | Y110A7A.10.1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | Phosphoinositide 3-kinase adapter subunit. | 0.900 |
Y71H2AM.2 | mtm-1 | Y71H2AM.2.1 | Y110A7A.5.1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.913 |
Y71H2AM.2 | mtm-3 | Y71H2AM.2.1 | T24A11.1a.1 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | Myotubularin-related protein 3; Preferentially dephosphorylates phosphatidylinositol 3- phosphate (PI3P), and has some activity towards phosphatidylinositol 3,5-bisphosphate (PI35P). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (By similarity). Positively regulates autophagy and is recruited to autophagosomes by PI3P where it catalyzes PI3P turnover to promote autophagosome maturation. Thought to have a role in maintenance of muscle function. Involved in locomotion and lifespan determination. | 0.917 |
Y71H2AM.2 | mtm-6 | Y71H2AM.2.1 | F53A2.8b.2 | Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). | Myotubularin-related protein 6; May dephosphorylate phosphatidylinositol-3-phosphate (PI3P). In association with mtm-9, plays a role in endosome trafficking probably by regulating phosphatidylinositol-3-phosphate levels. Regulates fluid phase endocytosis in coelomocytes. Controls the endosomal localization of sorting nexin snx-3 and the levels of sorting receptor mig-14. By regulating the retrograde transport of mig-14, may be involved in the secretion of Wnt ligands such as egl-20. Regulates posterior migration of QL neuroblast descendants and the anterior migration of QR neuroblast d [...] | 0.902 |
Y75B8A.24 | W09C5.7 | Y75B8A.24.1 | W09C5.7a.1 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | SAC domain-containing protein. | 0.910 |
Y75B8A.24 | aap-1 | Y75B8A.24.1 | Y110A7A.10.1 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Phosphoinositide 3-kinase adapter subunit. | 0.920 |
Y75B8A.24 | mtm-1 | Y75B8A.24.1 | Y110A7A.5.1 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Myotubularin-related protein 1; Dephosphorylates phosphatidylinositol 3-phosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Negatively regulates accumulation of PI3P on intracellular vesicles. Negatively regulates phagocytosis of apoptotic cells probably by limiting the recruitment and/or the activation of ced-5, ced-2 and ced-12 complex. In addition, may positively regulate phagosome maturation by promoting recycling of apoptotic receptor ced-1 back to the plasma membrane. Essential for embryonic and larval development. May promote migration of distal tip cells ; B [...] | 0.908 |