STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
snf-12Transporter. (1022 aa)    
Predicted Functional Partners:
sta-2
Signal transducer and activator of transcription b; Carries out a dual function: signal transduction and activation of transcription (By similarity). By regulating the up- regulation in the epidermis of antimicrobial peptides nlp-29, plays a role in resistance to fungal infection and in the response to physical wounding and phorbol ester PMA treatment. Belongs to the transcription factor STAT family.
   
 
 0.964
nipi-4
Protein nipi-4; Pseudokinase which plays a role in resistance to fungal infection by promoting expression of antimicrobial peptides (nlp-29, nlp-31, nlp-34, cnc-1, cnc-2 and cnc-4) in the epidermis. In addition, up-regulates nlp-29 expression upon physical wounding and in response to phorbol ester PMA treatment; Belongs to the protein kinase superfamily. Tyr protein kinase family.
   
  
 0.717
nlp-29
Neuropeptide-like protein 29; Antimicrobial peptides that have antibacterial activity against the Gram-negative bacteria S.marcescens. Has antifungal activity against D.coniospora. May play a role in response to physical injury and osmotic stress ; Belongs to the YARP (YGGW-amide related peptide) family.
   
  
 0.703
dcar-1
G_PROTEIN_RECEP_F1_2 domain-containing protein.
   
  
 0.699
sut-1
SUppressor of Tau pathology.
      
 0.692
nlp-31
Neuropeptide-like protein 31; Antimicrobial peptides that have antifungal activity against D.coniospora. Has weak antibacterial activity against Gram-positive bacteria M.luteus and Gram-negative E.coli.
      
 0.660
cnc-5
CaeNaCin (Caenorhabditis bacteriocin).
      
 0.614
nlp-34
Neuropeptide-Like Protein.
      
 0.610
T11G6.3
MFS domain-containing protein.
  
  
 0.553
nipi-3
Protein nipi-3; By regulating the up-regulation in the epidermis of antimicrobial peptides nlp-29 and nlp-31, plays a role in resistance to fungal infection.
      
 0.546
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.