STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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dkf-2Serine/threonine-protein kinase dkf-2; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of PMK-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily. (1095 aa)    
Predicted Functional Partners:
dkf-1
Serine/threonine-protein kinase dkf-1; Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, independently of PKC. Role in the regulation of growth and neuromuscular control of movement. Involved in immune response to S.aureus bacterium by activating transcription factor hlh-30 downstream of phospholipase plc-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
  
  
0.823
egl-8
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta egl-8; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) which plays an important role in the regulation of intracellular signaling cascades (By similarity). Required in the nervous system to modulate neuronal activity. Facilitates synaptic transmission at neuromuscular junctions by regulating the release of acetylcholine from the motor neurons and thus affecting locomotion. Plays a role in efficient egg laying and defecation. Involved in axon regeneration [...]
   
  
 0.673
C55B7.10
Protein kinase domain-containing protein.
    
 
 0.667
dgk-5
Putative diacylglycerol kinase K06A1.6.
   
  
 0.483
vhp-1
Tyrosine-protein phosphatase vhp-1; Acts preferentially on the c-Jun N-terminal kinase (JNK) and p38 MAPKs. Plays an important role in the heavy metal stress response and in axon regeneration by negatively regulating the kgb-1 (JNK-like) and the pmk-1 (p38-type) MAPK signaling pathways. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
   
  
 0.477
F49F1.5
ShKT domain-containing protein.
      
 0.468
sedl-1
Probable trafficking protein particle complex subunit 2; May play a role in vesicular transport from endoplasmic reticulum to Golgi. Required for the systemic spread of the RNAi response; Belongs to the TRAPP small subunits family. Sedlin subfamily.
      
 0.465
spp-9
Saposin B-type domain-containing protein.
      
 0.461
gbb-1
Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by gbb-1 and gbb-2 (By similarity). Within the heterodimeric GABA receptor, only gbb-1 seems to bind agonists, while gbb-2 mediates coupling to G proteins (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (By similarity). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates po [...]
      
 0.461
grp-1
GTP exchange factor for ARFs 1; Promotes guanine-nucleotide exchange on ARF. Promotes the activation of ARF through replacement of GDP with GTP (By similarity). Plays a role in cell shedding during embryogenesis, probably by promoting the endocytosis of cell adhesion molecules.
      
 0.452
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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