node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C50F4.16 | ndx-1 | C50F4.16.1 | T26E3.2.1 | Nudix hydrolase domain-containing protein. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.668 |
C50F4.16 | ndx-2 | C50F4.16.1 | W02G9.1.1 | Nudix hydrolase domain-containing protein. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.669 |
C50F4.16 | ndx-4 | C50F4.16.1 | Y37H9A.6.1 | Nudix hydrolase domain-containing protein. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. | 0.545 |
F52C12.1 | agt-1 | F52C12.1a.1 | Y62E10A.5a.1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | DNA_binding_1 domain-containing protein. | 0.705 |
F52C12.1 | agt-2 | F52C12.1a.1 | F09E5.13.1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | AlkylGuanine DNA alkylTransferase. | 0.753 |
F52C12.1 | ndx-1 | F52C12.1a.1 | T26E3.2.1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.697 |
F52C12.1 | ung-1 | F52C12.1a.1 | Y56A3A.29a.1 | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.661 |
agt-1 | F52C12.1 | Y62E10A.5a.1 | F52C12.1a.1 | DNA_binding_1 domain-containing protein. | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | 0.705 |
agt-1 | agt-2 | Y62E10A.5a.1 | F09E5.13.1 | DNA_binding_1 domain-containing protein. | AlkylGuanine DNA alkylTransferase. | 0.907 |
agt-1 | ndx-1 | Y62E10A.5a.1 | T26E3.2.1 | DNA_binding_1 domain-containing protein. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.665 |
agt-1 | ung-1 | Y62E10A.5a.1 | Y56A3A.29a.1 | DNA_binding_1 domain-containing protein. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.792 |
agt-2 | F52C12.1 | F09E5.13.1 | F52C12.1a.1 | AlkylGuanine DNA alkylTransferase. | Probable tyrosyl-DNA phosphodiesterase; DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead- end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. May have low 3'exonuclease activity and may be able to remove a sin [...] | 0.753 |
agt-2 | agt-1 | F09E5.13.1 | Y62E10A.5a.1 | AlkylGuanine DNA alkylTransferase. | DNA_binding_1 domain-containing protein. | 0.907 |
agt-2 | ndx-1 | F09E5.13.1 | T26E3.2.1 | AlkylGuanine DNA alkylTransferase. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.690 |
agt-2 | ung-1 | F09E5.13.1 | Y56A3A.29a.1 | AlkylGuanine DNA alkylTransferase. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.697 |
clk-2 | dut-1 | C07H6.6.1 | K07A1.2.3 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Deoxyuridinetriphosphatase. | 0.575 |
clk-2 | ndx-1 | C07H6.6.1 | T26E3.2.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Putative nudix hydrolase 1; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.662 |
clk-2 | ndx-2 | C07H6.6.1 | W02G9.1.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Putative nudix hydrolase 2; Probably mediates the hydrolysis of some nucleoside diphosphate derivatives; Belongs to the Nudix hydrolase family. | 0.808 |
clk-2 | ndx-4 | C07H6.6.1 | Y37H9A.6.1 | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. | 0.469 |
dut-1 | clk-2 | K07A1.2.3 | C07H6.6.1 | Deoxyuridinetriphosphatase. | Telomere length regulation protein clk-2; DNA damage checkpoint protein required for DNA damage-induced cell cycle arrest and apoptosis, thereby playing a role in genome stability. Regulator of telomere length. Belongs to the TEL2 family. | 0.575 |