node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F32D8.12 | F32D8.14 | F32D8.12a.2 | F32D8.14a.1 | FAD-binding PCMH-type domain-containing protein. | Protein YIPF. | 0.986 |
F32D8.12 | F32D8.4 | F32D8.12a.2 | F32D8.4.1 | FAD-binding PCMH-type domain-containing protein. | PIH1 domain-containing protein. | 0.987 |
F32D8.12 | lrk-1 | F32D8.12a.2 | T27C10.6.1 | FAD-binding PCMH-type domain-containing protein. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.703 |
F32D8.14 | F32D8.12 | F32D8.14a.1 | F32D8.12a.2 | Protein YIPF. | FAD-binding PCMH-type domain-containing protein. | 0.986 |
F32D8.14 | F32D8.4 | F32D8.14a.1 | F32D8.4.1 | Protein YIPF. | PIH1 domain-containing protein. | 0.977 |
F32D8.14 | lrk-1 | F32D8.14a.1 | T27C10.6.1 | Protein YIPF. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.702 |
F32D8.4 | F32D8.12 | F32D8.4.1 | F32D8.12a.2 | PIH1 domain-containing protein. | FAD-binding PCMH-type domain-containing protein. | 0.987 |
F32D8.4 | F32D8.14 | F32D8.4.1 | F32D8.14a.1 | PIH1 domain-containing protein. | Protein YIPF. | 0.977 |
F32D8.4 | lrk-1 | F32D8.4.1 | T27C10.6.1 | PIH1 domain-containing protein. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.703 |
apb-3 | lrk-1 | R11A5.1a.1 | T27C10.6.1 | AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.723 |
catp-6 | djr-1.1 | W08D2.5a.1 | B0432.2.1 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. | 0.852 |
catp-6 | djr-1.2 | W08D2.5a.1 | C49G7.11.1 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Glutathione-independent glyoxalase DJR-1.2; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. Protects dopaminergic neurons from glyoxal-dependent neuronal degeneration; Belongs to the peptidase C56 family. DJ-1 subfamily. | 0.879 |
catp-6 | lrk-1 | W08D2.5a.1 | T27C10.6.1 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.860 |
catp-6 | pdr-1 | W08D2.5a.1 | K08E3.7a.2 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.790 |
catp-6 | pink-1 | W08D2.5a.1 | EEED8.9.1 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. | 0.566 |
catp-6 | vps-35 | W08D2.5a.1 | F59G1.3a.2 | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. | 0.717 |
djr-1.1 | catp-6 | B0432.2.1 | W08D2.5a.1 | Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. | Probable cation-transporting ATPase W08D2.5; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. | 0.852 |
djr-1.1 | lrk-1 | B0432.2.1 | T27C10.6.1 | Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. | Leucine-rich repeat serine/threonine-protein kinase 1; Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. | 0.855 |
djr-1.1 | pdr-1 | B0432.2.1 | K08E3.7a.2 | Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.988 |
djr-1.1 | pink-1 | B0432.2.1 | EEED8.9.1 | Glutathione-independent glyoxalase DJR-1.1; Catalyzes the conversion of methylglyoxal (MG) or glyoxal (GO) to D-lactate or glycolic acid respectively in a single glutathione (GSH)-independent step. May play a role in detoxifying endogenously produced glyoxals. Involved in protection against glyoxal-induced cell death. | Serine/threonine-protein kinase pink-1, mitochondrial; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins (By similarity). Plays a role in mitophagy. | 0.913 |