node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ceh-16 | unc-37 | C13G5.1.1 | W02D3.9.2 | Homeobox protein engrailed-like ceh-16; Required in the seam cells during embryonic development. Represses the fusion of the seam cells with the neighboring dorsal and ventral epidermal cells by repressing the expression of the fusion effector eff-1. Required for early seam cell differentiation. Triggers the expression of elt-5 and other seam cell markers and is indispensable for alae formation (a hallmark of seam cell differentiation). Required for the maintenance of correct boundaries between the lateral rows of seam cells and the ventral and dorsal row of epidermal cells during embr [...] | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.894 |
ctbp-1 | hda-1 | F49E10.5a.1 | C53A5.3.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.892 |
ctbp-1 | pop-1 | F49E10.5a.1 | W10C8.2.1 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | 0.934 |
ctbp-1 | unc-37 | F49E10.5a.1 | W02D3.9.2 | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.850 |
hda-1 | ctbp-1 | C53A5.3.1 | F49E10.5a.1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | 0.892 |
hda-1 | pop-1 | C53A5.3.1 | W10C8.2.1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | 0.710 |
hda-1 | unc-37 | C53A5.3.1 | W02D3.9.2 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.873 |
lin-22 | pop-1 | Y54G2A.1.1 | W10C8.2.1 | BHLH domain-containing protein. | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | 0.554 |
lin-22 | rnt-1 | Y54G2A.1.1 | B0414.2.2 | BHLH domain-containing protein. | Runt domain-containing protein. | 0.546 |
lin-22 | unc-37 | Y54G2A.1.1 | W02D3.9.2 | BHLH domain-containing protein. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.919 |
lsy-22 | unc-37 | F27D4.2a.1 | W02D3.9.2 | Uncharacterized protein. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.930 |
mab-9 | unc-37 | T27A1.6.1 | W02D3.9.2 | T-box protein 12; Involved in cell fate determination; required to pattern the posterior hindgut. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.895 |
mab-9 | unc-4 | T27A1.6.1 | F26C11.2.1 | T-box protein 12; Involved in cell fate determination; required to pattern the posterior hindgut. | Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. | 0.717 |
mls-1 | unc-37 | H14A12.4.1 | W02D3.9.2 | T-box transcription factor mls-1; Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.763 |
mls-1 | unc-4 | H14A12.4.1 | F26C11.2.1 | T-box transcription factor mls-1; Probable transcription factor required for the cell fate specification of non-striated uterine muscle precursor cells. Furthermore, may function with the transcriptional corepressor unc-37. | Homeobox protein unc-4; Transcription factor that regulates synaptic specificity. Determines the pattern of synaptic input to VA motor neurons. Acts together with unc-37 by repressing the expression of VB-specific genes such as ceh-12, thereby preventing the adoption of VB motor neurons. Has no role in axonal guidance or outgrowth. Belongs to the paired homeobox family. Unc-4 subfamily. | 0.436 |
pop-1 | ctbp-1 | W10C8.2.1 | F49E10.5a.1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | C-terminal-binding protein 1; Binds DNA and represses gene expression. Plays a role in regulation of life span, possibly by regulating transcription of genes important for lipid metabolism. | 0.934 |
pop-1 | hda-1 | W10C8.2.1 | C53A5.3.1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in the endoderm determination possibly by repressing end-1 expression. Also involved in vulval development, possibly by repressing lag-2 expression. In association with akir-1, plays a role in regula [...] | 0.710 |
pop-1 | lin-22 | W10C8.2.1 | Y54G2A.1.1 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | BHLH domain-containing protein. | 0.554 |
pop-1 | rnt-1 | W10C8.2.1 | B0414.2.2 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | Runt domain-containing protein. | 0.853 |
pop-1 | unc-37 | W10C8.2.1 | W02D3.9.2 | Protein pop-1; Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos. Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape. Represses expression of target genes via its interaction with hda-1 histone deacetylase. Required for specification of the M lineage-derived coelomocyte and sex myoblast fate. Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors. | Transcription factor unc-37; Transcriptional corepressor that functions with the neural specificity gene unc-4 to govern motor neuron identity. May function with transcription factor mls-1 to promote uterine muscle specification and formation. | 0.976 |