STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pig-1Maternal embryonic leucine zipper kinase; Serine/threonine-protein kinase involved in cell autonomous neuroblast asymmetric divisions that generate one precursor cell and one apoptotic cell by controlling spindle positioning, myosin distribution and the segregation of cell fate determinants. Promotes cell shedding during embryogenesis, probably through the endocytosis-mediated removal of cell adhesion molecules such as hmp-1 from the cell surface. May act downstream of par-4/strd-1/mop-25 to regulate cell shedding. (706 aa)    
Predicted Functional Partners:
ndc-80
Kinetochore protein ndc-80; Acts as a component of the essential kinetochore-associated ndc-80 complex, which is required for chromosome segregation in mitosis and meiosis and spindle checkpoint activity. Plays a role in kinetochore assembly and recruits the checkpoint protein mdf-2 and the spindly-like protein spdl-1 to unattached kinetochores. Mediates the formation of end-on kinetochore-microtubule attachments through recruitment of spdl-1. The ndc-80 complex synergistically enhances the affinity of the ska-1 complex for microtubules and may allow the ndc-80 complex to track depolym [...]
   
  
 0.924
bmk-1
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
   
  
 0.903
exo-1
EXOnuclease.
   
  
 0.893
mdf-2
HORMA domain-containing protein.
   
 
 0.890
zen-4
Kinesin-like protein.
   
 
 0.885
C30G12.6
Uncharacterized protein C30G12.6.
   
  
 0.880
ect-2
ECT2 (Mammalian Rho GEF) homolog.
   
 
 0.873
pch-2
Putative pachytene checkpoint protein 2; Plays a key role in chromosome recombination during meiosis.
   
  
 0.871
spd-1
SPD-1.
   
 
 0.868
fkh-8
Fork-head domain-containing protein.
   
 
 0.846
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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