STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cacn-1Cactin; Plays a role during early embryonic development. Required for the distal tip cell migration at the end of larval development and for gonad morphogenesis. (657 aa)    
Predicted Functional Partners:
prp-17
WD_REPEATS_REGION domain-containing protein.
   
 
 0.946
Y69A2AR.21
Uncharacterized protein.
   
 
 0.893
let-858
Pre-mRNA-splicing factor CWC22 homolog; Required for pre-mRNA splicing and for exon-junction complex (EJC) assembly. Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay (By similarity). Required for early embryogenesis and tissue differentiation; Belongs to the CWC22 family.
   
 
  0.876
mog-5
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-5; Could act late in the splicing of pre-mRNA and mediate the release of the spliced mRNA from spliceosomes; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily.
   
 
 0.873
rsr-1
PWI domain-containing protein.
   
 
 0.854
sacy-1
Suppressor of ACY-4 sterility; Belongs to the DEAD box helicase family.
   
 
 0.853
ccdc-55
Nuclear speckle splicing regulatory protein 1 homolog; Required for the cessation of distal tip cell migration at the end of larval morphogenesis; Belongs to the NSRP1 family.
   
 
 0.846
F53F4.14
Sde2_N_Ubi domain-containing protein.
   
 0.836
cyn-12
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
   
 
 0.825
Y66D12A.8
Uncharacterized protein.
   
  0.823
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.