STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sma-5Mitogen-activated protein kinase sma-5; Serine/threonine-protein kinase involved in the postembryonic regulation of body size, mainly through control of cell growth. In particular, controls the volume of intestine, muscles and hypodermis. In addition, regulates growth, intestinal granule distribution, lifespan and number of offspring. (509 aa)    
Predicted Functional Partners:
dbl-1
TGF_BETA_2 domain-containing protein.
   
 
 0.764
scd-2
ALK tyrosine kinase receptor homolog scd-2; Probable tyrosine-protein kinase receptor which regulates the dauer/non-dauer developmental decision probably by controlling daf-3 transcriptional activity in parallel or together with the TGF-beta pathway. Regulates integration of conflicting sensory cues in AIA interneurons. May act as a receptor for hen-1.
   
 
 0.751
C49F5.5
TAZ-type domain-containing protein.
    
 
 0.713
soc-1
Multisubstrate adapter protein soc-1; Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma- aminobutyric acid (GABA)receptor-mediated sensitivity to muscimol. Regulates synaptic levels of nAchR receptor subunit lev-1 and unc-38, and GABA receptor subunit unc-49 in the nerve cord, probably downstream of egl-15. Regulates motility. During the [...]
    
 
 0.708
C49F5.6
Uncharacterized protein.
      
 0.698
C49F5.7
Uncharacterized protein.
      
 0.698
ifo-1
Intermediate Filament Organize.
   
 
 0.681
sek-4
Protein kinase domain-containing protein.
  
 
 0.665
C49F5.3
Uncharacterized protein.
   
 
 0.642
E02D9.1
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
  
 
0.625
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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