STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcy-25Receptor-type guanylate cyclase gcy-25; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1034 aa)    
Predicted Functional Partners:
rgs-10
Regulator of G-protein signaling rgs-10; Shown to have a role in viability and embryogenesis.
      
 0.701
T04D3.5
Uncharacterized protein.
      
 0.660
gcy-15
Receptor-type guanylate cyclase gcy-15; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
 
 
0.516
egl-4
cGMP-dependent protein kinase egl-4; Promotes chemoreceptor gene expression in response to increased cGMP levels by antagonizing the gene repression functions of the class II HDAC hda-4 and the mef-2 transcription factor. Regulates gene expression via recruitment of a histone deacetylase complex containing hda-2, saeg-1 and saeg-2. Represses body size and lifespan through the dbl-1 and insulin pathways, respectively. May also signal through daf-3 and/or daf-5. Role in egg-laying, dauer formation and motility. Regulates behavioral responses to various chemosensory stimuli in sensory neu [...]
  
 
 0.481
gcy-34
Soluble guanylate cyclase gcy-34; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May be involved in sensitivity to quinine by regulating egl-4 activity through the production of cGMP. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.451
gcy-37
Soluble guanylate cyclase gcy-37; Synthesizes cyclic GMP (cGMP) from GTP (By similarity). May play a role in sensory neurons; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.447
gcy-20
Receptor-type guanylate cyclase gcy-20; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity).
  
  
0.438
pkg-2
Protein Kinase, cGMP-dependent.
  
 
 0.437
gcy-35
Soluble guanylate cyclase gcy-35; Plays a central role in social feeding behavior and oxygen sensation by synthesizing 3',5'-cyclic guanosine monophosphate (cGMP) from GTP. Oxygen, which binds to its heme-binding sites, probably regulates social behavior by modulating its activity. cGMP is a common second messenger in sensory transduction and is implicated in oxygen sensation. Indeed, C.elegans exhibits a strong behavioral preference for 5-12% oxygen, avoiding higher and lower oxygen levels; a higher level of oxygen inducing a naturally polymorphic social feeding behavior. Involved in [...]
  
  
0.427
gcy-17
Receptor-type guanylate cyclase gcy-17; Guanylate cyclase involved in the production of the second messenger cGMP (By similarity); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  
  
0.425
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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