STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
exc-4Chloride intracellular channel exc-4; May insert into membranes and form chloride ion channels. Involved in the formation of the excretory canal. Required to prevent cystic lumenal expansions in the excretory cell. Not required for formation of the initial tube, but is required for regulating the size of the tube lumen as it grows. (290 aa)    
Predicted Functional Partners:
exc-9
LIM zinc-binding domain-containing protein.
      
 0.758
yap-1
Yes-associated protein homolog 1; Plays a role in thermal stress response and in aging.
      
 0.748
exc-5
Uncharacterized protein.
      
 0.741
sir-2.1
NAD-dependent protein deacetylase sir-2.1; NAD-dependent deacetylase (By similarity). Required for a reduction of the 'Lys-16' acetylation of histone H4 (H4K16ac) on dosage-compensated X chromosomes in hermaphrodites. Plays a role in germ cell and somatic cell apoptosis in response to DNA damage. Functions upstream of daf-16 in the insulin-like signaling pathway, promoting daf-16 mediated transcriptional activation and increased lifespan. May also regulate lifespan independently of daf-16 by modulating the transcription of genes involved in the stress response of the endoplasmic reticu [...]
      
 0.736
T25C8.1
FGGY_N domain-containing protein.
      
 0.694
cogc-5
Conserved Oligomeric Golgi (COG) Component.
      
 0.611
exl-1
Chloride intracellular channel exl-1; Probable chloride channel; Belongs to the chloride channel CLIC family.
    
 
0.601
aqp-8
AQuaPorin or aquaglyceroporin related; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.549
aqp-9
Aquaporin; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.549
aqp-11
Aquaporin; Belongs to the MIP/aquaporin (TC 1.A.8) family.
      
 0.542
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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