STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mxt-1Eukaryotic translation initiation factor 4E-binding protein Mextli homolog; Plays a role in promoting translation. (507 aa)    
Predicted Functional Partners:
ife-3
Eukaryotic translation initiation factor 4E-3; Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. All 5 eIF4E proteins bind monomethyl cap structures. Only ife-1, ife-2 and ife-5 bind trimethyl cap structures which result from trans-splicing. Translation of trimethyl cap structure mRNAs may be regulated by intracellular redox state; disulfide bonds change the width and depth of the cap-binding cavity determining selectivit [...]
    
 
 0.986
T10E9.14
Uncharacterized protein.
      
 0.759
fubl-3
FUBp (FUBP) Like.
      
 0.758
fbxa-183
F-box domain-containing protein.
      
 0.758
F54D1.1
Uncharacterized protein.
      
 0.758
K11D12.9
RING-type domain-containing protein.
   
  
 0.743
B0280.17
KH domain-containing protein.
      
 0.741
pes-4
Patterned Expression Site.
   
  
 0.715
inx-13
Innexin; Structural component of the gap junctions. Belongs to the pannexin family.
   
  
 0.709
dhhc-2
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
   
  
 0.706
Your Current Organism:
Caenorhabditis elegans
NCBI taxonomy Id: 6239
Other names: C. elegans, Rhabditis elegans, roundworm
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